Figure 3 | npj Aging and Mechanisms of Disease

Figure 3

From: Metformin decreases progerin expression and alleviates pathological defects of Hutchinson–Gilford progeria syndrome cells

Figure 3

Metformin improves nuclear shape organization in HGPS MSCs. (a) Typical nuclear shape organization observed in HGPS MSCs stained for lamin A/C. (b) Lamin A/C immunostaining in HGPS MSCs following 48 h of treatment with 5 mmol/l metformin and 1 μmol/l tipifarnib (FTI). (c) Quantification of nuclear shape abnormalities following 48 h of treatment with 5 mmol/l metformin and 1 μmol/l tipifarnib (FTI). Statistical analysis was performed by one-way analysis of variance (ANOVA), using Dunnett’s comparison test. Values of P<0.05 were considered significant (***P<0.001). HGPS, Hutchinson–Gilford progeria syndrome; FTI, farnesyl transferase inhibitor; Met, metformin; MSC, mesenchymal stem cell.

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