Table 1 Baseline characteristics of patients with osteoporotic fracture according to BC diagnosis (n=1193)

From: Breast cancer survivors are at an increased risk for osteoporotic fractures not explained by lower BMD: a retrospective analysis

Variable

BC (n=62)

No BC (n=1,131)

P value

Age at first fracture

68.8 (±8.8)

68.8 (±10.2)

0.969a

BMI

29.3 (±4.8)

29.6 (±5.6)

0.735a

BMI

30

39 (62.9)

637 (56.3)

0.658b

 30.1–35

15 (24.2)

309 (27.3)

 

 35.1–40

7 (11.3)

139 (12.3)

 

40.1

1 (1.6)

46 (4.1)

 

BMD, g/cm 2

 Femoral neck

0.77 (±0.11)

0.76 (±0.12)

0.317a

 Total hip

0.84 (±0.13)

0.82 (±0.13)

0.164a

 Spine

0.96 (±0.15)

0.95 (±0.16)

0.450a

BMD T-score

 Femoral neck

−1.72 (±0.94)

−1.85 (±1.00)

0.330a

 Total hip

−1.32 (±1.12)

−1.52 (±1.10)

0.169a

 Spine

−1.80 (±1.23)

−1.94 (±1.36)

0.450a

BMD Z-score

 Femoral neck

−0.37 (±0.84)

−0.46 (±0.88)

0.401a

 Total hip

−0.16 (±1.03)

−0.31 (±0.94)

0.220a

 Spine

−0.29 (±1.34)

−0.43 (±1.36)

0.425a

VitD, ng/ml (n=465)

21.4 (±9.9) (n=28)

19.9 (±9.7) (n=437)

0.431a

VitD, ng/ml

 <20

14 (50.0)

234 (53.5)

0.715b

20

14 (50.0)

203 (46.5)

 

PTH, pg/ml (n=203)

48.7 (±34.0) (n=9)

65.7 (±58.1) (n=194)

0.384a

PTH, pg/ml

72

6 (66.7)

143 (73.7)

0.640b

 >72

3 (33.3)

51 (26.3)

 

Medication use (N, %)

 Topical steroids (>6 months, during 2 years before BMD)

2 (3.2)

55 (4.9)

0.556b

 Systemic steroids (>3 months, during 2 years before BMD)

2 (3.2)

96 (8.5)

0.142b

 Hormone replacement therapy (during 2 years before BMD)

13 (21.0)

244 (21.6)

0.910b

 Vitamin D (during the last 12 months before BMD)

1 (1.6)

106 (9.4)

0.037b

 Bisphosphonates (during 2 years before BMD)

8 (12.9)

296 (26.2)

0.020b

 Bisphosphonates (ever)

39 (62.9)

694 (61.4)

0.808b

 Anticonvulsants (during 2 years before BMD)

4 (6.5)

62 (5.5)

0.745b

  1. Abbreviations: BC, breast cancer; BMI, body mass index; BMD, bone mineral density; PTH, parathyroid hormone; VitD, vitamin D.
  2. a Statistical analysis: Student's t-test.
  3. bStatistical analysis: χ2-test.