Table 2 Multivariable Cox regression analysis for the development of brain as the first site of distant relapse among 852 patients with complete clinicopathological data in the 855Met cohort
From: αB-crystallin expression in breast cancer is associated with brain metastasis
Breast tumors a | Hazard ratio to brain mets as first site (95% CI) | P-value |
|---|---|---|
CRYAB | 1.2 (1.0–1.4) | 0.021 |
ER positive (n=596) vs. negative (n=256) | 0.4 (0.2–0.9) | 0.025 |
Nodal status positive (n=158) vs. negative (n=694) | 1.0 (0.5–2.0) | 0.9 |
Age (continuous) | 0.98 (0.9–1.0) | 0.078 |
PAM50 | 0.036 | |
LumA | 1 | |
LumB | 4.7 (1.7–13) | 0.0031 |
HER2 enriched | 2.9 (0.9–9.3) | 0.066 |
Basal like | 1.3 (0.4–4.7) | 0.66 |
Normal like | 1.7 (0.5–5.6) | 0.39 |
