Table 5 Multivariable logistic regression analysis for the development of any brain metastasis and brain as the first site of relapse in the BCCA cohort
From: αB-crystallin expression in breast cancer is associated with brain metastasis
Odds to any brain mets (95% CI), (events=141) | P-value | Odds to brain as first distant site (95% CI), (events=46) | P-value | |
|---|---|---|---|---|
Tumor size | ||||
⩽2 cm (n=375) | 1 | 1 | ||
2–5 cm (n=525) | 1.13 (0.76–1.69) | 0.54 | 0.70 (0.37–1.33) | 0.28 |
>5 cm (n=69) | 0.39 (0·13–1·18) | 0.095 | ||
Nodal status | ||||
Negative (n=374) | 1 | 1 | ||
Positive (n=595) | 0.53 (0·34–0·82) | 0.005 | 0.55 (0.28–1.08) | 0.082 |
Grade | ||||
1 or 2 (n=336) | 1 | 1 | ||
3 (n=633) | 1.2 (0·76–1·86) | 0.441 | 1.19 (0.57–2.48) | 0.65 |
Any initial chemo | ||||
No (n=648) | 1 | 1 | ||
Yes (n=321) | 1.46 (0.92–2.30) | 0.11 | 0.36 (0.19–0.71) | 0.003 |
Any initial hormonal | ||||
No (n=556) | 1 | 1 | ||
Yes (n=413) | 0.79 (0.50–1.24) | 0.3 | 0.91 (0.45–1.84) | 0.79 |
ER | ||||
Negative (n=316) | 1 | 1 | ||
Positive (n=653) | 0.58 (0.37–0.91) | 0.018 | 0.58 (0.28–1.24) | 0.16 |
HER2 | ||||
Negative (n=783) | 1 | 1 | ||
Positive (n=186) | 1.72 (1.08–2.73) | 0.023 | 1.88 (0.89–3.96) | 0.096 |
αB-crystallin | ||||
Negative (n=842) | 1 | 1 | ||
Positive (n=127) | 2.99 (1.83–4.89) | <0.0001 | 3.15 (1.43–6.95) | 0.005 |
