Figure 2 | npj Biofilms and Microbiomes

Figure 2

From: Tobramycin and bicarbonate synergise to kill planktonic Pseudomonas aeruginosa, but antagonise to promote biofilm survival

Figure 2

Synergy between fixed combinations of bicarbonate and tobramycin in killing P. aeruginosa (a) antibiotic-resistant mutant strain #1 and clinical CF isolates (b) 5914M, (c) 3488D and (d) 3470C. Error bars represent s.e.m.; N=3. For this, the bicarbonate concentration associated with the lowest ΣFIC value for the select strain was plotted against varying tobramycin concentrations tested. For all four strains thus examined, addition of bicarbonate reduces the concentration of tobramycin required to inhibit planktonic P. aeruginosa cells even at tobramycin concentrations much lower than that needed to produce synergy.

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