Figure 3 | npj Biofilms and Microbiomes

Figure 3

From: Tobramycin and bicarbonate synergise to kill planktonic Pseudomonas aeruginosa, but antagonise to promote biofilm survival

Figure 3

Time-kill assays demonstrating the synergy between bicarbonate and tobramycin against P. aeruginosa strains (a) PAO1, (b) antibiotic-resistant PA14 mutant #1 and (c) 5913C. Concentrations of tobramycin and bicarbonate tested represent the combinations that produced the lowest ΣFIC value. For strain PAO1, 0.25 μg/ml tobramycin and 5 mmol bicarbonate; for antibiotic-resistant PA14 mutant #1, 1 μg/ml tobramycin and 5 mmol bicarbonate; and for strain 5913C, 1 μg/ml tobramycin and 5 mmol bicarbonate were tested alone and in combination. Error bars represent s.e.m. (in some cases error bars are smaller than symbols). N=3.

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