Figure 1
From: Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response
Isoform switching in hypoxia increases the abundance of unproductive transcripts. (a) Multiple splicing events affect the majority of alternatively spliced genes. A3SS, alternative 3′ start site; A5SS, alternative 5′ start site; AFE, alternative first exon; ALE, alternative last exon; MXE, mutually exclusive exons; RI, retained intron; SE, spliced exon. (b) Inclusion or exclusion of exons in response to hypoxia, detected by MATS. Categories as a. (c) Overall expression levels of genes that switch between ‘protein-coding’ and ‘retained-intron’ major isoform between normoxia and hypoxia.
