Figure 3
From: Hypoxia-driven splicing into noncoding isoforms regulates the DNA damage response
Switch from coding to noncoding transcripts is a signature of colorectal tumours. (a) Change in major isoform class between ‘tumour-free’ and ‘with tumour’ samples in TCGA colorectal carcinomas; Orange: enriched in ‘with tumour’ samples. (b) Unsupervised clustering of colorectal tumour samples based on major isoform type: NMD, ‘nonsense-mediated decay’; Processed, ‘processed transcript’; RI, ‘retained Intron’. (c) Proportion of noncoding major isoforms detected across colorectal tumour samples stratified by patient status at last contact: ‘tumour free’ (purple) and ‘with tumour’ (green). Data from TCGA. (d) Average expression level of genes changing from coding to noncoding major isoform (CoNCo) stratified by patient status on last contact. (e) Gene ontology terms found enriched among CoNCo genes.
