Table 1 Reproducible gene expression changes of myosin, paramyosin, unc-87, and dim-1 are induced by spaceflight

From: Microgravity elicits reproducible alterations in cytoskeletal and metabolic gene and protein expression in space-flown Caenorhabditis elegans

Gene name

Description

CERISE (current experiment)

ICE-First (previous experiment)

  

Expression change log 2 [μG/1 G]

t-test P-value

Expression change log 2 [μG/1 G]

t-test P-value

myo-3

Myosin heavy chain A

−0.89

0.00

−0.34

0.00

unc-54

Myosin heavy chain B

−0.49

0.01

−0.45

0.01

unc-15

Paramyosin

−0.62

0.01

−0.33

0.04

unc-87

Maintain the myofilament structure

−0.25

0.05

−0.34

0.00

dim-1

Required for muscle assembly

−0.11

0.03

−0.53

0.00

  1. Abbreviations: CERISE, C. elegans RNA Interference in Space Experiment; ICE-First, the first International C. elegans Experiment in Space.
  2. CERISE and ICE-First experiments were carried out in 2009 and 2004, respectively. The worms were synchronously cultivated in a bacterial diet for 4 days from L1 larvae in CERISE. Adult worms frozen on ISS were used for the microarray analysis. In ICE-First, the worms were non-synchronously cultivated in a chemically defined diet for 10 days. Mixed stage worms frozen within 30 min of Soyuz landing were used for the analysis. Microarray analysis was performed in triplicate (n=3).
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