Table 4 Downregulated gene expression of the TCA cycle components
Gene name | Coding protein | Expression change log 2 [μG/1 G] | t-test P-value |
|---|---|---|---|
pdha-1 | Pyruvate dehydrogenase (Lipoamide) α1 | −0.45 | 0.00 |
C04C3.3 | Pyruvate dehydrogenase complex E1 β subunit | −0.36 | 0.00 |
dld-1 | Dihydrolipoamide dehydrogenase | −0.54 | 0.00 |
cts-1 | Citrate synthase | −0.76 | 0.00 |
aco-1 | Aconitase | −0.32 | 0.00 |
aco-2 | Aconitase | −0.14 | 0.01 |
idha-1 | NAD+-dependent mitochondrial isocitrate dehydrogenase α subunit | −0.64 | 0.00 |
idhb-1 | NAD+-dependent mitochondrial isocitrate dehydrogenase β subunit | −0.38 | 0.00 |
idhg-1 | NAD+-dependent mitochondrial isocitrate dehydrogenase γ subunit | −0.30 | 0.00 |
idhg-2 | NAD+-dependent mitochondrial isocitrate dehydrogenase γ subunit | −0.56 | 0.00 |
idh-2 | Mitochondrial isocitrate dehydrogenase | −0.30 | 0.00 |
gei-7 | Isocitrate lyase/malate synthase | −1.09 | 0.00 |
dlst-1 | Dihydrolipoamide S-succinyltransferase | −0.43 | 0.01 |
dld-1 | Dihydrolipoamide dehydrogenase | −0.54 | 0.00 |
sdha-1 | Succinate dehydrogenase complex, subunit A | −0.67 | 0.01 |
sdhb-1 | Succinate dehydrogenase complex, subunit B | −0.56 | 0.00 |
mev-1 | Succinate dehydrogenase complex, subunit C | −0.76 | 0.00 |
sdhd-1 | Succinate dehydrogenase complex, subunit D | −0.60 | 0.00 |
fum-1 | Fumarase | −0.56 | 0.00 |
mdh-1 | Malate dehydrogenase | −0.38 | 0.00 |
