Table 1 M. marinum genes that significantly altered expression when grown under LSMMG for both 40 h, and 4 days ~35 h (LSMMG/NG)

From: Exposure of Mycobacterium marinum to low-shear modeled microgravity: effect on growth, the transcriptome and survival under stress

Gene name

Function

RFC at 40 h

RFC at 4 days ~35 h

ltp1_1

Cell wall and cell processes

2.2

1.9

mmpL3

 

0.63

0.67

MMAR_0493-1

 

1.5

1.6

MMAR_1554-1

 

1.7

1.5

MMAR_2268-1

 

0.46

0.50

cydD

 

2.2

1.9

MMAR_3568-1

 

3.4

2.4

MMAR_3658-1

 

8.1

9.1

lsr2

 

0.48

0.57

fbpA

 

0.54

0.63

MMAR_0119-1

Conserved hypotheticals

1.9

1.7

MMAR_0519-1

 

0.39

0.35

MMAR_0853-1

 

9.1

9.0

MMAR_0982-1

 

0.46

0.51

MMAR_2771-1

 

1.7

2.2

MMAR_3007-1

 

1.7

1.6

MMAR_3010-1

 

1.8

1.9

MMAR_3070-1

 

2.2

1.8

MMAR_3088-1

 

1.8

1.5

MMAR_3549-1

 

0.24

0.29

MMAR_4248-1

 

3.8

2.2

MMAR_4306-1

 

8.9

4.9

MMAR_4498-1

 

3.5

5.1

MMAR_4609-1

 

2.1

2.4

MMAR_4647-1

 

3.0

1.5

MMAR_5103-1

 

0.39

0.42

MMAR_5106-1

 

0.43

0.58

MMAR_5437-1

 

1.5

1.8

MMAR_5455-1

 

1.8

1.5

rpsR1

Information pathway

0.55

0.57

rplA

 

0.58

0.65

rplJ

 

0.48

0.57

rplC

 

0.49

0.55

rplB

 

0.52

0.63

rplV

 

0.46

0.63

rpmC

 

0.61

0.64

rpsN

 

0.67

0.62

rpsE

 

0.51

0.63

infA

 

0.64

0.66

rpsD

 

0.65

0.64

rpoA

 

0.50

0.59

rplQ

 

0.52

0.57

rplM

 

0.61

0.60

rpsI

 

0.63

0.60

sigH

 

1.5

1.5

nrdE

 

1.8

2.2

hupB

 

0.42

0.66

rpsP

 

0.66

0.66

tsf

 

0.61

0.66

rplY

 

0.55

0.64

rnpA

 

0.57

0.58

celA

Intermediary metabolism

0.53

0.47

nirB

and respiration

0.39

0.48

hemC

 

0.48

0.48

mrsA

 

0.60

0.62

sdhB

 

0.59

0.81

sdhD

 

0.55

0.67

MMAR_1644-1

 

1.8

1.5

amiC

 

0.63

0.64

csd

 

0.49

0.50

MMAR_2557-1

 

1.7

1.9

MMAR_2844-1

 

0.46

0.58

folE_1

 

1.6

1.9

glnA2

 

0.57

0.62

MMAR_3558-1

intermediary metabolism and respiration

0.23

0.07

mobA

 

0.33

0.52

porB

 

0.33

0.53

porA

 

0.31

0.46

putA

 

4.0

2.6

pth

 

0.49

0.61

MMAR_4497-1

 

3.3

5.0

panD

 

0.47

0.54

panC

 

0.56

0.58

desA3_2

Lipid metabolism

3.9

3.6

desA3

 

2.2

1.8

fadE23

 

1.6

1.9

pks15/1

 

0.53

0.66

fabG3_1

 

2.1

1.7

fabD

 

0.32

0.48

kasA

 

0.28

0.37

kasB

 

0.28

0.37

accD6

 

0.29

0.36

accA2

 

0.63

0.58

fadB

 

0.57

0.59

pks13

 

0.38

0.57

fadD32

 

0.33

0.55

MMAR_0641-1

PE/PPE

2.5

2.8

MMAR_4562-1

 

1.9

2.3

MMAR_4899-1

 

2.6

2.0

hspR

Regulatory protein

2.6

4.4

whiB3

 

0.16

0.38

whiB7

 

0.65

2.6

MMAR_2281-1

 

0.49

0.60

MMAR_3703-1

 

3.1

2.7

MMAR_5069-1

 

0.64

0.46

hsp

Virulence, adaptation

5.7

40.8

dnaK

detoxification

3.5

5.38

  1. Only genes that altered significantly by ⩾1.5-fold at both time points are shown. RFC is the ratio of the normalized mean count values for LSMMG over the normalized mean count values for NG.
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