Table 3 The direction of association of cis-eQTL level with the rs3129,882 genotype depends on ethnicity

From: Common genetic variant association with altered HLA expression, synergy with pyrethroid exposure, and risk for Parkinson’s disease: an observational and case–control study

HLA-DRB1

ρ

P value

HLA-DRB5

ρ

P value

Utah Caucasians

0.199

0.038

Utah Caucasians

0.516

9.30E-09

Han Chinese

−0.281

0.0124

Han Chinese

−0.038

0.7396

Gujarati Indians in Houston, TX, USA

−0.017

0.8774

Gujarati Indians in Houston, TX, USA

0.242

0.0283

Japanese in Tokyo, Japan

0.038

0.7364

Japanese in Tokyo, Japan

−0.131

0.2393

Luhya in Kenya

−0.347

0.0014

Luhya in Kenya

−0.315

0.0039

Mexicans in Los Angeles, CA, USA

0.052

0.7333

Mexicans in Los Angeles, CA, USA

0.193

0.2029

Masaii in Kenya

−0.338

5.20E−05

Masaii in Kenya

−0.037

0.666

Yoruba in Nigeria

−0.317

8.00E−04

Yoruba in Nigeria

−0.122

0.2079

  1. Abbreviations: eQTL, expression-quantitative trait locus; SNP, single-nucleotide polymorphism.
  2. The level of HLA-DRB1 and HLA-DRB5 cis-eQTLs were significantly associated with rs3129882 genotype and were within 500 kb of the rs3129882 SNP in the HapMap3 database. Association was reported as Spearman’s rank correlation (ρ) with P value for all the ethnic groups within the database.
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