Table 3 Management and outcome indices hypothesis testing: (a) all patients with COPD; (b) all patients with very severe COPD
Index | Adjustment | Period | Period, age, sex, townsend | ||
|---|---|---|---|---|---|
Coef (95% CI) | P-value | Coef (95% CI) | P-value | ||
(a) | |||||
Mean age at diagnosis: linear, n=65,900 | Annual change | −0.18 (−0.21, −0.15) | <0.01 | −0.19 (−0.22, −0.16) | <0.01 |
Sex | — | — | 0.21 (0.04, 0.38) | 0.02 | |
Townsend 1 | — | — | 1.00 | ||
Townsend 2 | — | — | −0.49 (−0.78, −0.19) | ||
Townsend 3 | — | — | −1.64 (−1.92, −1.35) | ||
Townsend 4 | — | — | −2.23 (−2.50, −1.95) | ||
Townsend 5 | — | — | −3.74 (−4.03, −3.45) | ||
Townsend missing | — | — | −1.80 (−2.23, −1.37) | <0.01 | |
Mean age at death: linear, n=20,932 | Annual change | 0.08 (0.04, 0.11) | <0.01 | 0.07 (0.04, 0.1) | <0.01 |
Sex | — | — | 0.56 (0.39, 0.73) | <0.01 | |
Townsend 1 (Ref) | — | — | 1.00 | ||
Townsend 2 | — | — | −0.19 (−0.48, 0.11) | ||
Townsend 3 | — | — | −0.48 (−0.77, −0.19) | ||
Townsend 4 | — | — | −1.03 (−1.3, −0.75) | ||
Townsend 5 | — | — | −1.5 (−1.79, −1.21) | ||
Townsend missing | — | — | 0.22 (−0.22, 0.67) | <0.01 | |
Proportion of patients with very severe COPD: odds ratio, n=52,311 | Annual change | 0.66 (0.62, 0.70) | <0.01 | 0.67 (0.64, 0.72) | <0.01 |
Age | — | — | 0.99 (0.99, 1.00) | <0.01 | |
Sex | — | — | 0.52 (0.48, 0.55) | <0.01 | |
Townsend 1 (Ref) | — | — | 1.00 | ||
Townsend 2 | — | — | 0.97 (0.88, 1.08) | ||
Townsend 3 | — | — | 1.01 (0.91, 1.11) | ||
Townsend 4 | — | — | 1.09 (0.99, 1.20) | ||
Townsend 5 | — | — | 1.10 (1.00, 1.22) | ||
Townsend missing | — | — | 0.99 (0.85, 1.17) | 0.03 | |
No. of oral corticosteroids: incident rate ratio, n=92,576 | Annual change | 1.05 (1.05, 1.05) | <0.01 | 1.05 (1.05, 1.05)a | <0.01 |
Age | — | — | 1.01 (1.01, 1.01) | <0.01 | |
Sex | — | — | 1.21 (1.20, 1.23) | <0.01 | |
Townsend 1 (Ref) | — | — | 1.00 | ||
Townsend 2 | — | — | 1.03 (1.01, 1.06) | ||
Townsend 3 | — | — | 1.07 (1.05, 1.10) | ||
Townsend 4 | — | — | 1.12 (1.10, 1.15) | ||
Townsend 5 | — | — | 1.20 (1.18, 1.23) | ||
Townsend missing | — | — | 1.08 (1.05, 1.12) | <0.01 | |
No. of consultations: incident rate ratio, n=92,576 | Annual change | 1.03 (1.03, 1.03) | <0.01 | 1.03 (1.03, 1.03)b | <0.01 |
Age | — | — | 1.01 (1.01, 1.01) | <0.01 | |
Sex | — | — | 1.08 (1.08, 1.08) | <0.01 | |
Townsend 1 (Ref) | — | — | 1.00 | ||
Townsend 2 | — | — | 0.99 (0.98, 1.00) | ||
Townsend 3 | — | — | 1.03 (1.03, 1.04) | ||
Townsend 4 | — | — | 1.01 (1.01, 1.02) | ||
Townsend 5 | — | — | 1.01 (1.00, 1.01) | ||
Townsend missing | — | — | 1.09 (1.08, 1.10) | <0.01 | |
(b) | |||||
Proportion of patients receiving triple therapy: incident rate ratio, n=6,456 | Annual change | 1.15 (1.14, 1.17) | <0.01 | 1.16 (1.14, 1.18) | 0.00 |
Age | — | — | 0.99 (0.99, 0.99) | 0.00 | |
Sex | — | — | 0.94 (0.88, 1.01) | 0.09 | |
Townsend 1 (Ref) | — | — | 1.04 (0.92, 1.16) | ||
Townsend 2 | — | — | 1.06 (0.95, 1.19) | ||
Townsend 3 | — | — | 1.07 (0.96, 1.19) | ||
Townsend 4 | — | — | 1.03 (0.92, 1.15) | ||
Townsend 5 | — | — | 0.98 (0.82, 1.17) | ||
Townsend missing | — | — | 1.16 (1.14, 1.18) | 0.77 | |
