Table A1 Ovid MEDLINE(R) 1946 to present with daily update—executed 10 May 2016

1

exp Asthma/ or Bronchial Spasm/ or exp Bronchoconstriction/ or (asthma* or wheez* or bronchoconstrict* or bronchial constrict* or bronch* constrict* or bronchial spasm or bronchospas*or bronch* spasm*).tw.

2

Bronchial Hyperreactivity/ or Respiratory Hypersensitivity/

3

1 or 2

4

(exacerb* or deteriorat* or aggravate* or acute* or status* or sever* or wors* or attack* or crisis or critical or hospital* or relapse or uncontrolled or poor* controlled).tw. or exp Recurrence/ or exp Disease Progression/ or exp Mortality/ or exp Death/

5

exp Emergency Service, Hospital/ or exp Emergency Medical Services/ or exp Hospitalisation/ or exp Hospitals/ or exp Intensive Care Units/ or exp Emergencies/ or (emergenc* or acute care or intensive care or intensive treatment unit* or hospital*).tw.

6

(admission* or admit* or attend* or visit* or present* or utilis* or utiliz* or use* or using).tw.

7

5 and 6

8

exp Primary Health Care/ or exp General Practice/ or exp Family Practice/ or exp Physicians/ or (physician* or doctor* or health care professional or general practice or asthma nurse or specialist nurse or GP).tw.

9

exp ‘Appointments and Schedules’/ or appointment*.tw. or visit*.tw.

10

(unscheduled or additional or increase*).tw.

11

8 and 9 and 10

12

exp Medicine/ or exp Therapeutics/ or exp Anti-Asthmatic Agents/ or exp Bronchodilator Agents/ or exp Adrenergic beta-Agonists/ or exp Cholinergic Antagonists/ or exp Steroids/ or exp Glucocorticoids/ or (medicin* or treatment or medication or steroid* or corticosteroid* or glucocorticosteroid* or inhaler* or beta agonist* or beta-2-agonist* or SABA or anticholinergic* or ICS).tw.

13

(rescue or supplement* or (step* adj up) or adjuvant or additional or increase*or augment*).tw.

14

12 and 13

15

exp Steroids/ or exp Glucocorticoids/ or (steroid* or corticosteroid* or glucocorticosteroid*).tw.

16

(systemic or oral or intravenous or intramuscular or injectable or parenteral or IV or IM).tw. or exp Injections, Intravenous/ or exp Administration, Intravenous/ or exp Injections, Intramuscular/ or exp Infusions, Parenteral/ or rescue.tw.

17

15 and 16

18

(((nocturnal or night* or sleep*) adj2 (symptom* or wheeze* or asthma or wakening or woken or disturb*)) or ((daily or daytime) adj2 (activit* adj2 disturb*))).tw.

19

exp Oxygen Inhalation Therapy/ or exp Intubation, Intratracheal/ or nebuli*.tw.

20

((increas* or wors* or aggravate*) and (frequenc* or sever* or symptom* or wheez* or breathless* or dyspn?a)).tw.

21

4 or 7 or 11 or 14 or 17 or 18 or 19 or 20

22

3 and 21

23

Risk Factors/ or Risk/ or (risk adj3 factor*).tw. or predict*.tw. or (risk* adj2 exacerb*).tw.

24

23 and 22

25

Animals/ not Humans/

26

24 not 25

27

Adult/ not Child/

28

26 not 27

29

(COPD.tw. or Pulmonary Disease, Chronic Obstructive/) not Asthma/

30

28 not 29

31

Comment/ or Letter/ or Editorial/ or Autobiography/ or Biography/ or Bibliography/ or Dictionary/ or Directory/ or Interactive Tutorial/ or Lectures/

32

30 not 31