Figure 4
From: From START to FINISH: computational analysis of cell cycle control in budding yeast
The roles of Polo kinase (Cdc5) in mitotic exit. (a) Overexpression of Cdc5 rescues the lethality of cdc15Δ cells, which lack MEN-dependent kinase activity. (b,c) Overexpression of Cdc5 promotes Cdc14 release in cells with blocked FEAR pathway, either by non-degradable Pds1 or by nocodazole. (d) Overexpression of Cdc5 promotes Cdc14 release in hydroxyurea-treated cells. These simulations agree well with experimental observations.37 MEN, mitotic exit network.
