Table 1 Predicted phenotypes of some mutant strains

From: From START to FINISH: computational analysis of cell cycle control in budding yeast

Mutant genotype

Predicted phenotype a

Confidence b

Experimental evidence

cln1Δ cln2Δ swi4Δ

Inviable

Robust

Inviable14

cln1Δ cln2Δ mbp1Δ

Viable

Fragile

Viable (unpublished)

cln1Δ cln2Δ cln3Δ cdc6Δ sic1Δ

Viable

Fragile

None

cln1Δ cln2Δ cln3Δ whi5Δ

Inviable

Robust

Inviable17

cln3Δ swi4Δ whi5Δ

Inviable

Robust

None

swi4Δ mbp1Δ whi5Δ

Inviable

Robust

Viable (unpublished)

swi4Δ mbp1Δ sic1Δ

Inviable

Fragile

None

swi4Δ mbp1Δ cdh1Δ

Inviable

Fragile

None

swi4Δ mbp1Δ GAL-BCK2

Inviable

Robust

Inviable22

swi4Δ mbp1Δ GAL-CLN3

Inviable

Robust

None

swi4Δ mbp1Δ GAL-CLB5

Viable

Robust

None

mbp1Δ mcm1Δ swi4Δ swi5Δ swi6Δ GAL-CLB2 GAL-CDC5 GAL-CDC20 GAL-CLN2(low) GAL-SIC1(low)

Viable

Fragile

None

  1. aNone of these mutant strains were included in the collection of 263 strains used to parametrize the model.
  2. bRobustness analysis of predicted phenotypes is described in the Supplementary Text.