Table 1 Statistical properties of yeast signal transduction maps constructed in this study

	Ion homeostasis	Nutrient adaptation	Osmotic stress	Oxidative stress	Heat shock	Pheromone response
Stimuli	H⁺, Na⁺, K⁺, Li⁺, Ca²⁺, Mg²⁺, Mn²⁺, Cu²⁺, Cd²⁺, Zn²⁺, Fe³⁺, alkali, citric acid, sorbic acid	Glucose, low glucose, amino acids, nitrogen source	Hyper-osmolarility, hypo-osmolarility, cold shock, DMSO, zymolyase	Oxidative stress	Heat shock	Pheromone
Number of species	1,082	580	586	517	481	217
Proteins	368	256	215	167	167	87
Complexes	137	110	79	61	49	71
Genes and RNAs	400	134	228	217	203	40
Other molecules ^a	121 (4)	49 (1)	40 (2)	42 (0)	19 (1)	6 (0)
Number of reactions	768	472	424	464	366	155
Associations and dissociations	105	99	62	83	36	46
State transitions	145	170	111	124	87	51
Transcriptions and translations	284	94	130	132	123	30
Transports	99	59	26	28	20	13
Number of References ^b	281	274	239	253	174	152

Abbreviation: DMSO, dimethyl sulfoxide.
^aOther molecules include simple molecules (e.g., ATP, glucose, NADH), ions, and drugs. The number of drugs is indicated in brackets, since drugs are not naturally present in yeast cells.
^bA full list of publications referred to in the maps is available in Supplementary Information S1.

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