Table 2 Distribution of bow–tie scores b(m) in each stress response pathway

From: Network analyses based on comprehensive molecular interaction maps reveal robust control structures in yeast stress response pathways

Bow–tie score b(m)

Ion homeostasis

Nutrient adaptation

Osmotic stress

Oxidative stress

Heat shock

Pheromone response

0.5–1.0 a

5

Sho1/Pbs2, Hog1, Pbs2, Hog1/Msn2, Hog1

12

cAMP, EGO complex, Sit4, TORC1, Tap42/TORC1, ATP, Sit4/Tap42/TORC1, fructose 1,6-biphosphate, fructose 6-phosphate, glucose 6-phosphate

6

Hog1/Msn2, Pbs2, Hog1, Sho1/Pbs2

8

Sit4, Msn2, Hyr1/Yap1/Ybp1, Yap1-Ox, Glc7/Reg1, Bmh2

5

cAMP, Cdc25, Cyr1/Srv2, Msn2, Bcy1

23

Cdc24/Far1/Ste4/Ste18, Ste4/Ste18, Bem1/GTP/Cdc42/Cdc24/Far1/Ste4/Ste18, Bem1/GTP/Cdc42/Cdc24/Far1/Ste4/Ste18/Ste20, GTP Gpa1/Ste4/Ste18,Ste5/Ste50/Ste11/Ste7/Kss1, Ste5/Ste50/Ste11/Ste7/Fus3, Ste12, Dig1/Dig2/Ste12, Kss1, a-factor/Ste3, alpha-factor/Ste2

0.2–0.5

3

28

14

30

19

7

<0.2

81

133

67

71

41

2

0

529

325

245

268

190

162

R2 coefficient b

0.3165

0.8881

0.6902

0.5531

0.2243

0.8096

  1. aFor molecules with very high bow–tie scores (0.5–1.0), the number of molecules in the map with bow–tie scores b(m) within this range are indicated above a list of molecules/complexes with these scores in each map. Molecules in different states (modification or localization) are represented without distinction. Instances separated with '/' indicate complexes.
  2. bR2 coefficient between bow–tie score and betweenness centrality.
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