Figure 1
Hopfield energy landscape of the first case study (GSE13201) from two different perspectives. The x and y axes represent the first and second principal components of the data; the z axis represents the energy E. The left panel show side views of the landscape; the elevation of each group on the landscape is clearly visible. The right panel shows the top view of the landscape; the trajectory of cell movement is visible in the (x,y) plane. P7 (EP7=−1320897) cells are positioned at the lowest level of the Hopfield energy landscape. The higher energies of the transient groups (P6 and P5, EP6=−755220 and EP5=−599724) are followed by a decrease in energy to P4 (EP4=−3307223) resulting in the observed trajectory.
