Figure 4 | npj Systems Biology and Applications

Figure 4

From: Integrating highly quantitative proteomics and genome-scale metabolic modeling to study pH adaptation in the human pathogen Enterococcus faecalis

Figure 4

Significant protein concentration changes in response to the pH shift (pH 7.5 t1, pH 7 t2, pH 6.5 t3−8). (a) Significant protein concentration changes per time point. Only proteins which are part of the model are shown. Upregulated reactions are indicated in blue, downregulated reactions in cyan. A list of the significant changes of time point t8 can be found in Table 1. A comprehensive list of all significant protein quantity changes for all time points can be found in the appendix Supplementary Table S10. (b) Increased expression of Rex-regulated proteins with respective P values. EF0255: L-lactate dehydrogenase (LDH1), EF1612: pyruvate formate-lyase activating enzyme, EF1613: pyruvate formate-lyase (PFL). (c) Cell membrane lipoteichoic acid precursor synthesis proteins. EF2881: [acyl-carrier-protein]:NADP+ oxidoreductase, EF0283: malonyl-[acyl-carrier-protein] C-acyltransferase, EF2644: phosphoglycerate mutase family protein, EF3112: phosphate acyltransferase. (d) Upregulated tRNA producing enzymes. EF1379: alanyl-tRNA synthetase, EF2406: glycyl-tRNA synthetase, EF1003: isoleucyl-tRNA synthetase, EF2931: valyl-tRNA synthetase. tRNA, transfer RNA.

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