Figure 5

Predicted changes in the flux distributions as computed with FVA between pH 7.5 and 6.5 involving protons. Upregulated fluxes (green) include the main glycolytic pathway, lactate production and degradation of L-arginine and L-serine, downregulated ones (blue) comprise fermentative reaction, the pentose-phosphate pathway (PGL) as well as one reaction from the amino acid pathway (GLUDy). Reactions not involving protons are omitted. The change in proton production per reaction is given in $\mathrm{mmol}{\mathrm{g}}_{\mathrm{DW}}^{-1}{\mathrm{h}}^{-1}$. ACt6, acetate transport in/out via proton symport; ASAD, aspartate-semialdehyde dehydrogenase; CITt6, citrate transport in/out via proton symport; CK, carbamate kinase; DHAK, dihydroxyacetone (glycerone) kinase; GAPD, glyceraldehyde-3-phosphate dehydrogenase (NAD); GLUDy, glutamate dehydrogenase (NADP); G6PDHy, glucose 6-phosphate dehydrogenase, HSDy, homoserine dehydrogenase (NADPH); OAADC, oxaloacetate decarboxylase; OCBT, ornithine carbamoyltransferase; PGL, 6-phosphogluconolactonase; SERt6, L-serine transport in/out via proton symport. The upper and lower bounds as well as the flux interval size are shown in Supplementary Figure S5.