Table 1 Experimental and predicted steady-state concentrations

From: Predictive model of thrombospondin-1 and vascular endothelial growth factor in breast tumor tissue

 

Predicted value mean±s.d.

Measured value

Cancer type and References

VEGF (pmol/l)a

178±8

8–389

Multiple, compiled in ref. 22

TSP1

 Total (pmol)

61±4

52–64b

Breast34

Hepatocellular carcinoma35

 Unbound (pmol/l)a

185±5

c

 

 Cleaved (nmol/l)a

2.2±0.06

c

 

MMP3

 Total (pmol)

162±0.02

160b

Oral squamous cell carcinoma33

 Unbound (nmol/l)a

9.0±5×10−3

c

 

MMP9

 Total (pmol)

161±0.1

160b

Oral squamous cell carcinoma33

 Active (% of total)

3%±8×10−4%

8%

Oral squamous cell carcinoma33

 Active (pmol/l)a

295±7

c

 
  1. a Refers to unbound protein in the available interstitial space.
  2. b The model predicts the extracellular protein concentrations, whereas experimental data reflect the total amount (extracellular and intracellular), as the tissue is homogenized prior to protein quantification. We assume that 50% of the total protein amount is localized to the extracellular space. This assumption can easily be changed, given more experimental data.
  3. c Model prediction, no data available.
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