Table 2 Analyses of SST mRNA level (nCi/g) in the OFC gray matter (A) and white matter (B) and PV mRNA level (nCi/g) in the OFC gray matter (C)

	% Change	Mean control	s.d. control	Mean schizophrenia	s.d. schizophrenia	t-value	F	df	P-value	Covariates
(A) SST—layers
I	−10	6.07	1.22	5.45	1.17	—	5.09	66	0.03*	pH, age at death
II	−67	24.69	11.10	8.20	2.97	—	160.31	65	3.31×10⁻¹⁹***	pH, age at death, RIN
III	−60	11.03	7.61	4.39	2.85	—	16.55	65	1.31×10⁻⁴***	pH, age at death, RIN
IV	−21	11.08	4.86	8.78	4.13	—	4.63	68	0.04*	pH, age at death
V	−45	18.75	8.58	10.29	4.60	—	24.99	66	4.51×10⁻⁶***	pH, age at death, RIN
VI	−21	12.73	4.67	10.09	4.11	—	6.20	65	0.02*	pH, age at death, RIN
(B) White matter	17	6.50	1.06	7.62	1.88	—	13.33	62	5.39×10⁻⁴***	pH, age at death
(C) PV—layers
I	0	6.83	0.75	6.83	1.21	—	0.55	64	0.46	PMI
II	−8	9.54	2.68	8.81	2.28	0.60	—	65	0.55	—
III	−18	12.74	3.69	10.50	3.31	2.59	—	64	0.01*	—
IV	−31	23.18	6.74	15.97	6.14	—	18.73	63	5.48×10⁻⁵***	pH
V	−13	13.91	5.06	12.06	4.36	—	3.93	64	0.05	Freezer (months)
VI	1	8.55	1.50	8.62	2.16	—	0.03	63	0.86	Freezer (months)

Abbreviations: OFC, orbital frontal cortex; PMI, postmortem interval; PV, parvalbumin; RIN, RNA integrity number; SST, somatostatin.
*P<0.05; ***P<0.001.

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