Table 3 (A) SST mRNA (qPCR), (B) SST layer II mRNA (in situ hybridization), (C) SST layer II mRNA+ cell density, (D) PV mRNA (qPCR), (E) FASR mRNA (qPCR), and (F) TNFSF13 (qPCR) correlation with other OFC measures

From: Relationship between somatostatin and death receptor expression in the orbital frontal cortex in schizophrenia: a postmortem brain mRNA study

 

Schizophrenia

Whole cohort

Control

 

r

P-value

r

P-value

r

P-value

(A) SST qPCR

 FASR

−0.391

0.018*

−0.243

0.043*

0.105

0.553

 TNFSF13

−0.282

0.095

−0.243

0.041*

−0.189

0.275

 GAD67 (LI–VI)

0.143

0.428

0.340

0.005**

0.437

0.01*

 NeuN (sIWMN)

−0.146

0.411

−0.222

0.073

−0.162

0.375

 GAD65/67 (sIWMN)

−0.249

0.176

−0.204

0.112

−0.038

0.837

(B) SST LII

 FASR

−0.485

0.004**

−0.415

4.79×10−4***

−0.215

0.223

 TNFSF13

−0.382

0.026*

−0.249

0.041*

−0.156

0.379

 GAD67 (LI–VI)

0.391

0.027*

0.559

1.06×10−6***

0.620

9.17×10−5***

 NeuN (sIWMN)

−0.233

0.191

−0.457

1.32×10−4***

−0.155

0.398

 GAD65/67 (sIWMN)

−0.226

0.229

−0.356

0.005**

−0.077

0.681

 Dlx1

0.085

0.631

0.308

0.009**

0.005

0.976

(C) SST LII mRNA+ cell density

 SST LII mRNA

0.475

9.14×10−4***

0.541

5.77×10−6***

0.519

0.002**

 FASR

−0.574

5.90×10−4***

−0.509

1.76×10−5***

−0.263

0.147

 TNFSF13

−0.452

0.011*

−0.336

0.007**

−0.187

0.306

 GAD67 (L I–VI)

0.387

0.042*

0.526

1.59×10−5***

0.575

5.82×10−4***

 NeuN (sIWMN)

−0.503

0.005**

−0.238

0.069

0.345

0.062

 GAD65/67 (sIWMN)

−0.178

0.384

−0.245

0.072

−0.165

0.393

(D) PV qPCR

 FASR

0.013

0.943

−0.004

0.975

−0.071

0.698

 TNFSF13

−0.251

0.139

−0.210

0.086

−0.137

0.454

 GAD67 (LI–VI)

0.166

0.363

0.170

0.179

0.245

0.176

 NeuN (sIWMN)

0.094

0.603

0.075

0.554

−0.052

0.782

(E) FASR qPCR

 TNFSF13

0.710

8.38×10−7***

0.607

1.53×10−8***

0.387

0.022*

 PV LIV

−0.164

0.362

−0.118

0.357

0.271

0.147

 GAD67 (LI–VI)

−0.452

0.008**

−0.341

0.005**

−0.021

0.906

 NeuN (sIWMN)

0.239

0.173

0.293

0.018*

0.154

0.409

(F) TNFSF13 qPCR

 PV LIII

−0.185

0.304

−0.089

0.487

0.073

0.697

 PV LIV

−0.257

0.142

−0.119

0.349

0.081

0.670

 PV LI–VI

−0.272

0.114

−0.105

0.396

0.176

0.326

  1. Abbreviations: FASR, FAS receptor; OFC, orbital frontal cortex; qPCR, quantitative PCR; PV, parvalbumin; sIWMN, superficial interstitial white matter neuron; SST, somatostatin.
  2. *P<0.05; **P<0.01; ***P<0.001.
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