Table 2 Pairwise comparisons for adjacent blocks of the 1H-fMRS paradigm for Glu, Gln, and Glx concentrations

Group	Resting	Stroop1	p(S1-B)	Recovery1	p(R1-S1)	Stroop2	p(S2-R1)	Recovery2	p(R2-S2)
HC
[Glu]	8.8±0.9	9.0±0.9	0.006	8.8±0.8	0.007	8.8±1.1	0.970	8.9±1.1	0.391
[Gln]	1.5±0.4	1.5±0.5	0.541	1.5±0.5	0.950	1.4±0.6	0.538	1.5±0.5	0.853
[Glx]	10.1±1.0	10.4±1.0	0.018	10.2±1.1	0.046	10.1±1.2	0.697	10.2±1.3	0.457
MDD
[Glu]	9.2±1.4	9.4±1.5	0.081	9.3±1.5	0.116	8.9±1.5	0.003	9.0±1.4	0.716
[Gln]	1.6±0.9	1.6±1.0	0.355	1.7±1.0	0.728	1.6±1.1	0.773	1.5±0.9	0.255
[Glx]	10.6±2.2	10.9±2.4	0.052	10.8±2.5	0.184	10.3±2.5	0.006	10.4±2.2	0.794
SZ
[Glu]	9.1±1.3	9.2±1.2	0.107	9.2±1.2	0.367	8.9±1.5	0.024	8.9±1.4	0.737
[Gln]	1.2±0.5	1.4±0.5	0.004	1.2±0.5	0.001	1.2±0.4	0.739	1.2±0.4	0.765
[Glx]	10.2±1.8	10.5±1.7	0.016	10.2±1.6	0.020	10.0±1.9	0.119	10.0±1.8	0.957
All
[Glu]	9.1±1.2	9.2±1.2	0.002	9.1±1.2	0.011	8.9±1.4	0.003	8.9±1.3	0.601
[Gln]	1.4±0.7	1.5±0.7	0.012	1.4±0.7	0.100	1.4±0.8	0.727	1.4±0.7	0.701
[Glx]	10.3±1.7	10.6±1.8	0.001	10.4±1.8	0.005	10.1±1.9	0.008	10.2±1.8	0.577

Abbreviations: All, the combination of all participants across groups; [Gln], The concentration of glutamine in mmol/kg_ww; [Glu], The concentration of glutamate in mmol/kg_ww; [Glx], The concentration of Glx (glutamate + glutamine) in mmol/kg_ww; HC, Healthy controls; MDD, Major Depressive Disorder; p(S1-B), Stroop1 vs resting, (alpha=0.05/4 (Bonferroni corrected); one-tailed (Glu, Glx), and two-tailed (Gln)), bolded values indicate statistical significance; p(S2-R1), Stroop2 vs Recovery1, (alpha=0.05/4 (Bonferroni corrected); two-tailed (Glu, Gln, Glx)), bolded values indicate statistical significance; p(R1-S1), Recovery1 vs Stroop1, (alpha=0.05/4 (Bonferroni corrected); one-tailed (Glu, Glx), and two-tailed (Gln)), bolded values indicate statistical significance.; p(R2-S2), Recovery2 vs Stroop2, (alpha=0.05/4 (Bonferroni corrected); two-tailed (Glu, Gln, Glx)), bolded values indicate statistical significance; SZ, Schizophrenia

Search