Table 1 Patients demographics and PANSS score before and after treatment

From: Biological pathways modulated by antipsychotics in the blood plasma of schizophrenia patients and their association to a clinical response

ID patient	T0 raw PANSS				T0 corrected PANSS				T6 raw PANSS				T6 corrected PANSS				Good response ⩾50% corrected PANSS total reduction		First episode patient	Drug naive	Illness duration [years]	Medication	Gender	Age	BMI	Smoking
	PANSS P1-P7	PANSS N1-N7	PANSS G1-G16	PANSS total	PANSS P1-P7	PANSS N1-N7	PANSS G1-G16	PANSS total	PANSS P1-P7	PANSS N1-N7	PANSS G1-G16	PANSS total	PANSS P1-P7	PANSS N1-N7	PANSS G1-G16	PANSS total	Relative PANSS total improvement T0-T6	All patients
99	7	17	37	61	0	10	21	31	7	11	29	50	0	4	13	17	0.45	Bad responder	Yes	Yes	0	Quetiapie	F	31	19.7	No
105	28	32	63	123	21	25	47	93	33	32	64	141	26	25	48	99	−0.06	Bad responder	No	No	15	Quetiapie	M	47	21.8	Yes
129	22	29	45	101	15	22	29	66	14	24	32	74	7	17	16	40	0.39	Bad responder	No	No		Risperidoe	F	49	23.9	Yes
133	17	34	49	106	10	27	33	70	10	18	28	59	3	11	12	26	0.63	Good responder	Yes	No	0	Olanzapie	F	25	24.0	Yes
136	24	24	46	104	17	17	30	64	15	11	26	55	8	4	10	22	0.66	Good responder	No	No		Risperidoe	F	44	27.4	No
140	25	26	58	115	18	19	42	79	16	15	34	72	9	8	18	35	0.56	Good responder	No	No	7	Risperidoe	M	30	22.2	Yes
147	31	31	55	126	24	24	39	87	12	24	39	82	5	17	23	45	0.48	Bad responder	Yes	Yes	0	Olanzapie	M	25	28.1	Yes
151	26	9	40	79	19	2	24	45	8	8	19	38	1	1	3	5	0.89	Good responder	No	No	0	Olanzapie	F	45	30.5	Yes
156	17	16	28	64	10	9	12	31	12	13	24	54	5	6	8	19	0.39	Bad responder	No	No	2	Risperidoe	M	42	32.9	Yes
162	20	16	37	76	13	9	21	43	7	14	19	43	0	7	3	10	0.77	Good responder	Yes	Yes	0	Risperidoe	M	19	20.2	Yes
208	38	18	35	109	31	11	19	61	12	9	20	44	5	2	4	11	0.82	Good responder	No	No	9	Olanzapie	M	28	25.3	Yes
247	25	25	55	111	18	18	39	75	15	8	27	54	8	1	11	20	0.73	Good responder	No	No	7	Risperidoe	M	40	23.0	Yes
249	22	41	41	107	15	34	25	74	17	31	37	90	10	24	21	55	0.26	Bad responder	No	No	19	Risperidoe	M	44	17.7	Yes
260	21	11	31	76	14	4	15	33	8	24	24	59	1	17	8	26	0.21	Bad responder	No	No	1	Olanzapie	M	22	27.5	No
277	26	12	38	83	19	5	22	46	9	7	21	42	2	0	5	7	0.85	Good responder	Yes	Yes	0	Risperidoe	F	20	22.2	No
278	37	29	58	137	30	22	42	94	13	22	30	71	6	15	14	35	0.63	Good responder	No	No	9	Risperidoe	M	31	22.8	Yes
331	31	9	41	92	24	2	25	51	15	8	31	61	8	1	15	24	0.53	Good responder	No	No	23	Olanzapie	F	39	29.8	Yes
332	23	29	39	95	16	22	23	61	16	24	31	75	9	17	15	41	0.33	Bad responder	Yes	Yes	0	Risperidoe	F	26	22.1	No
363	27	25	41	100	20	18	25	63	10	16	23	52	3	9	7	19	0.70	Good responder	Yes	Yes	0	Risperidoe	M	25	20.1	Yes
366	28	16	40	93	21	9	24	54	9	10	21	43	2	3	5	10	0.81	Good responder	Yes	Yes	0	Olanzapie	M	34	27.7	No
368	34	20	61	132	27	13	45	85	17	20	47	91	10	13	31	54	0.36	Bad responder	Yes	Yes	0	Risperidoe	M	16	26.5	Yes
370	26	9	39	81	19	2	23	44	9	15	27	54	2	8	11	21	0.52	Good responder	Yes	Yes	0	Risperidoe	M	31	24.4	No
371	35	14	43	104	28	7	27	62	8	7	20	38	1	0	4	5	0.92	Good responder	No	No	6	Risperidoe	F	48	37.2	No
375	18	30	50	101	11	23	34	68	21	27	42	97	14	20	26	60	0.12	Bad responder	Yes	Yes	0	Quetiapie	M	23	22.0	Yes
391	25	11	51	97	18	4	35	57	11	9	22	45	4	2	6	12	0.79	Good responder	No	No	32	Quetiapie	F	55	29.8	No
400	19	27	54	108	12	20	38	70	7	11	20	41	0	4	4	8	0.89	Good responder	No	No		Quetiapie	F	32	22.7	No
404	29	10	40	97	22	3	24	49	7	7	20	40	0	0	4	4	0.92	Good responder	No	No	6	Olanzapie	M	45	26.4	Yes
408	15	13	52	87	8	6	36	50	15	19	41	82	8	12	25	45	0.10	Bad responder	No	No	2	Quetiapie	F	27	22.2	Yes
410	12	26	47	91	5	19	31	55	20	23	48	98	13	16	32	61	−0.11	Bad responder	No	No		Olanzapie	F	50	24.1	Yes
422	28	41	45	121	21	34	29	84	7	9	24	43	0	2	8	10	0.88	Good responder	No	No	11	Risperidoe	M	34	23.6	Yes
426	26	23	46	105	19	16	30	65	12	10	22	47	5	3	6	14	0.78	Good responder	No	No	7	Risperidoe	M	30	21.5	Yes
428	20	10	60	94	13	3	44	60	19	12	50	89	12	5	34	51	0.15	Bad responder	Yes	Yes	0	Quetiapie	F	38	32.9	Yes
431	24	26	42	95	17	19	26	62	12	14	26	55	5	7	10	22	0.65	Good responder	Yes	Yes	0	Olanzapie	M	29	21.1	Yes
440	33	12	45	104	26	5	29	60	13	11	33	65	6	4	17	27	0.55	Good responder	No	No	32	Olanzapie	F	59	35.0	No
452	14	20	36	80	7	13	20	40	17	9	26	65	10	2	10	22	0.45	Bad responder	No	No	15	Risperidoe	M	36	22.4	No
454	22	16	48	94	15	9	32	56	7	7	16	33	0	0	0	0	1.00	Good responder	Yes	Yes	0	Risperidoe	M	34	22.2	Yes
464	25	18	37	94	18	11	21	50	8	14	25	50	1	7	9	17	0.66	Good responder	Yes	Yes	0	Risperidoe	F	66	31.6	Yes
468	19	18	48	88	12	11	32	55	9	18	24	54	2	11	8	21	0.62	Good responder	No	No	1	Risperidoe	M	35	18.3	No
474	28	14	51	99	21	7	35	63	32	21	42	105	25	14	26	65	−0.03	Bad responder	No	No	11	Quetiapie	M	32	25.0	Yes
476	17	17	37	76	10	10	21	41	14	11	32	64	7	4	16	27	0.34	Bad responder	No	No	7	Quetiapie	M	25	22.0	Yes
479	24	14	44	91	17	7	28	52	13	9	26	52	6	2	10	18	0.65	Good responder	Yes	Yes	0	Olanzapie	F	53	20.1	Yes
487	37	7	62	115	30	0	46	76	13	17	32	70	6	10	16	32	0.58	Good responder	Yes	Yes	0	Quetiapie	M	39	21.1	Yes
493	28	29	51	116	21	22	35	78	15	21	29	68	8	14	13	35	0.55	Good responder	Yes	Yes	0	Risperidoe	M	50	19.7	Yes
520	16	24	38	90	9	17	22	48	9	11	25	49	2	4	9	15	0.69	Good responder	No	No	0	Quetiapie	F	31	28.7	Yes
521	27	17	50	102	20	10	34	64	10	9	21	43	3	2	5	10	0.84	Good responder	No	No	10	Olanzapie	M	32	30.8	No
522	17	7	40	67	10	0	24	34	17	9	27	57	10	2	11	23	0.32	Bad responder	Yes	Yes	0	Quetiapie	M	26	21.0	Yes
524	21	13	40	79	14	6	24	44	12	14	29	58	5	7	13	25	0.43	Bad responder	Yes	Yes	0	Olanzapie	F	36	22.0	Yes
526	26	38	71	138	19	31	55	105	16	29	39	87	9	22	23	54	0.49	Bad responder	Yes	Yes	0	Olanzapie	M	23	22.2	No
539	24	27	58	112	17	20	42	79	21	16	49	94	14	9	33	56	0.29	Bad responder	No	No	3	Quetiapie	M	28	23.2	Yes
541	16	7	30	53	9	0	14	23	13	7	25	56	6	0	9	15	0.35	Bad responder	No	No	34	Risperidoe	M	53	24.8	Yes
545	28	12	35	84	21	5	19	45	15	7	23	55	8	0	7	15	0.67	Good responder	No	No	0	Olanzapie	F	50	28.6	Yes
568	21	30	43	100	14	23	27	64	16	26	28	73	9	19	12	40	0.38	Bad responder	No	No	10	Risperidoe	F	56	29.1	No
570	26	12	45	89	19	5	29	53	11	12	30	56	4	5	14	23	0.57	Good responder	No	No	3	Risperidoe	M	36	20.4	Yes
572	16	7	25	51	9	0	9	18	7	7	17	34	0	0	1	1	0.94	Good responder	Yes	Yes	0	Quetiapie	F	36	21.9	Yes
579	14	18	34	75	7	11	18	36	11	7	21	42	4	0	5	9	0.75	Good responder	Yes	Yes	0	Olanzapie	F	36	30.3	Yes
592	38	25	43	122	31	18	27	76	15	7	41	68	8	0	25	33	0.57	Good responder	No	No	14	Olanzapie	M	30	31.1	No
663	23	11	22	59	16	4	6	26	10	7	18	38	3	0	2	5	0.81	Good responder	No	No	21	Risperidoe	M	51	30.4	No
800	16	15	30	65	9	8	14	31	11	8	18	40	4	1	2	7	0.77	Good responder	No	No	15	Risperidoe	M	58	20.6	No

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Table 1 Patients demographics and PANSS score before and after treatment

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