Table 2 Differentially expressed proteins in responders before and after 6 weeks of antipsychotic treatment

From: Biological pathways modulated by antipsychotics in the blood plasma of schizophrenia patients and their association to a clinical response

Entry

Entry name

Gene name

Score

Mass

Resp T0×T6

Reg

StDev

Number of peptides

Description

Biological process

Molecular class

Molecular function

Q92828

COR2A_HUMAN

CORO2A

35

60,239

0.12

Down

6.913

2

Coronin-2A

Cell communication and signaling

Unclassified

Molecular function unknown

O00622

CYR61_HUMAN

CYR61

41

44,165

0.03

Down

1.779

2

Protein CYR61

Cell communication and signaling

Extracellular matrix protein

Extracellular matrix structural constituent

Q5THR3

EFCB6_HUMAN

EFCAB6

35

174,702

3.57

Up

7.015

2

EF-hand calcium-binding domain-containing protein 6

Cell communication and signaling

Calcium binding protein

Calcium ion binding

O94887

FARP2_HUMAN

FARP2

33

120,725

11.93

Up

3.329

2

FERM, RhoGEF and pleckstrin domain-containing protein 2

Cell communication and signaling

Cytoskeletal protein

Structural constituent of cytoskeleton

P78527

PRKDC_HUMAN

PRKDC

40

473,749

41.97

Up

1.948

2

DNA-dependent protein kinase catalytic subunit

Cell communication and signaling

Serine/threonine kinase

Protein serine/threonine kinase activity

Q15036

SNX17_HUMAN

SNX17

44

53,153

0.05

Down

3.201

4

Sorting nexin-17

Cell communication and signaling

Adapter molecule

Receptor signaling complex scaffold activity

O43294

TGFI1_HUMAN

TGFB1I1

39

51,321

0.31

Down

1.962

2

Transforming growth factor beta-1-induced transcript 1 protein

Cell communication and signaling

Transcription regulatory protein

Transcription regulator activity

Q9UPZ6

THS7A_HUMAN

THSD7A

30

192,854

0.03

Down

1.223

2

Thrombospondin type-1 domain-containing protein 7A

Cell communication and signaling

Unclassified

Molecular function unknown

Q6F5E8

LR16C_HUMAN

RLTPR

39

156,133

20.44

Up

1.954

2

Leucine-rich repeat-containing protein 16C

Cell communication and signaling

Unclassified

Molecular function unknown

P00740

FA9_HUMAN

F9

154

53,114

0.36

Down

6.308

2

Coagulation factor IX

Protein metabolism

Coagulation factor

Extracellular matrix binding

P34931

HS71L_HUMAN

HSPA1L

45

70,730

0.45

Down

2.631

4

Heat shock 70 kDa protein 1-like

Protein metabolism

Heat shock protein

Heat shock protein activity

Q06033

ITIH3_HUMAN

ITIH3

299

100,072

1.52

Up

1.254

5

Inter-alpha-trypsin inhibitor heavy chain H3

Protein metabolism

Protease inhibitor

Protease inhibitor activity

P09001

RM03_HUMAN

MRPL3

28

38,893

0.27

Down

1.813

2

39S ribosomal protein L3, mitochondrial

Protein metabolism

Ribosomal subunit

Structural constituent of ribosome

P01011

AACT_HUMAN

SERPINA3

1317

47,792

1.48

Up

1.282

34

Alpha-1-antichymotrypsin

Protein metabolism

Protease inhibitor

Protease inhibitor activity

A1L167

YE019_HUMAN

UBE2QL1

71

18,440

0.06

Down

4.273

2

Ubiquitin-conjugating enzyme E2Q-like protein 1

Protein metabolism

Unclassified

Molecular function unknown

Q9UHC1

MLH3_HUMAN

MLH3

28

166,060

0.05

Down

2.706

2

DNA mismatch repair protein Mlh3

Reg. nucleic acid metab

DNA repair protein

Protein binding

O75592

MYCB2_HUMAN

MYCBP2

35

517,856

6.52

Up

5.641

2

Probable E3 ubiquitin-protein ligase MYCBP2

Reg. nucleic acid metab

Transcription regulatory protein

Transcription regulator activity

Q8IZQ8

MYCD_HUMAN

MYOCD

34

102,561

0.43

Down

1.59

2

Myocardin

Reg. nucleic acid metab

Transcription factor

Transcription factor activity

O15350

P73_HUMAN

TP73

21

70,206

0.03

Down

1.951

2

Tumor protein p73

Reg. nucleic acid metab

Transcription factor

Transcription factor activity

Q9UL58

ZN215_HUMAN

ZNF215

40

60,922

0.11

Down

5.344

2

Zinc finger protein 215

Reg. nucleic acid metab

DNA binding protein

DNA binding

Q2M3G0

ABCB5_HUMAN

ABCB5

31

90,173

64.78

Up

1.559

2

ATP-binding cassette sub-family B member 5

Transport

Integral membrane protein

Transporter activity

Q86UQ4

ABCAD_HUMAN

ABCA13

70

580,604

12.73

Up

5.368

2

ATP-binding cassette sub-family A member 13

Transport

Transport/cargo protein

Transporter activity

P02768

ALBU_HUMAN

ALB

123

71,317

0.04

Down

1.8

6

Serum albumin

Transport

Transport/cargo protein

Transporter activity

P06727

APOA4_HUMAN

APOA4

1502

45,371

0.51

Down

1.061

7

Apolipoprotein A-IV

Transport

Transport/cargo protein

Transporter activity

P21796

VDAC1_HUMAN

VDAC1

26

30,868

26.82

Up

1.167

2

Voltage-dependent anion-selective channel protein 1

Transport

Voltage-gated channel

Voltage-gated ion channel activity

Q9BXS0

COPA1_HUMAN

COL25A1

28

65,145

0.06

Down

2.02

2

Collagen alpha-1(XXV) chain

Cell growth and maintenance

Extracellular matrix protein

Extracellular matrix structural constituent

Q16610

ECM1_HUMAN

ECM1

435

62,232

2.43

Up

6.347

2

Extracellular matrix protein 1

Cell growth and maintenance

Extracellular matrix protein

Extracellular matrix structural constituent

Q92556

ELMO1_HUMAN

ELMO1

46

84,517

0.13

Down

7.738

5

Engulfment and cell motility protein 1

Cell growth and maintenance

Motor protein

Motor activity

P20929

NEBU_HUMAN

NEB

85

775,419

0.08

Down

7.593

6

Nebulin

Cell growth and maintenance

Cytoskeletal protein

Structural constituent of cytoskeleton

P23258

TBG1_HUMAN

TUBG1

27

51,480

0.46

Down

2.748

2

Tubulin gamma-1 chain

Cell growth and maintenance

Cytoskeletal protein

Structural constituent of cytoskeleton

O43866

CD5L_HUMAN

CD5L

201

39,603

3.03

Up

5.29

2

CD5 antigen-like

Immune response

Secreted polypeptide

Defense/immunity protein activity

Q5JU67

CI117_HUMAN

C9orf117

47

60,667

0.02

Down

1.229

2

Uncharacterized protein C9orf117

Unknown

Unclassified

Molecular function unknown

Q8IV32

CCD71_HUMAN

CCDC71

26

49,759

32.45

Up

4.607

2

Coiled-coil domain-containing protein 71

Unknown

Unclassified

Molecular function unknown

Q96AQ1

CC74A_HUMAN

CCDC74A

31

41,808

12.33

Up

1.079

2

Coiled-coil domain-containing protein 74A

Unknown

Unclassified

Molecular function unknown

Q6IPU0

CENPP_HUMAN

CENPP

38

33,429

20.20

Up

1.001

2

Centromere protein P

Unknown

Unclassified

Molecular function unknown

Q6P4F2

ADXL_HUMAN

FDX1L

22

19,737

2.01

Up

1.341

2

Adrenodoxin-like protein, mitochondrial

Unknown

Unclassified

Molecular function unknown

Q6ZVN6

YO003_HUMAN

HSD47

60

33,173

0.29

Down

1.027

3

Uncharacterized protein HSD47

Unknown

Unclassified

Molecular function unknown

Q8N485

LIX1_HUMAN

LIX1

58

32,213

0.23

Down

2.73

5

Protein limb expression 1 homolog

Unknown

Unclassified

Molecular function unknown

Q969T7

5NT3L_HUMAN

NT5C3B

40

33,893

9.21

Up

1.238

3

7-methylguanosine phosphate-specific 5'-nucleotidase

Unknown

Unclassified

Molecular function unknown

O15018

PDZD2_HUMAN

PDZD2

29

303,964

25.23

Up

4.449

2

PDZ domain-containing protein 2

Unknown

Unclassified

Molecular function unknown

Q7Z6W1

TMCO2_HUMAN

TMCO2

22

20,287

2.59

Up

1.144

2

Transmembrane and coiled-coil domain-containing protein 2

Unknown

Integral membrane protein

Molecular function unknown

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