Table 3 Differentially expressed proteins in non-responders before and after 6 weeks of antipsychotic treatment

From: Biological pathways modulated by antipsychotics in the blood plasma of schizophrenia patients and their association to a clinical response

Entry

Entry name

Gene name

Score

Mass

Non Resp T0×T6

Reg

StDev

Number of peptides

Description

Biological process

Molecular class

Molecular function

P10645

CMGA_HUMAN

CHGA

31

50,829

0.02

Down

1.972

3

Chromogranin-A

Cell communication and signaling

Secreted polypeptide

Defense/immunity protein activity

Q92828

COR2A_HUMAN

CORO2A

35

60,239

9.12

Up

1.259

2

Coronin-2A

Cell communication and signaling

Unclassified

Molecular function unknown

O00622

CYR61_HUMAN

CYR61

41

44,165

0.42

Down

1.137

2

Protein CYR61

Cell communication and signaling

Extracellular matrix protein

Extracellular matrix structural constituent

Q5THR3

EFCB6_HUMAN

EFCAB6

35

174,702

0.01

Down

5.227

2

EF-hand calcium-binding domain-containing protein 6

Cell communication and signaling

Calcium binding protein

Calcium ion binding

O94887

FARP2_HUMAN

FARP2

33

120,725

4.14

Up

1.445

2

FERM, RhoGEF and pleckstrin domain-containing protein 2

Cell communication and signaling

Cytoskeletal protein

Structural constituent of cytoskeleton

Q8WXI7

MUC16_HUMAN

MUC16

29

2,359,682

0.04

Down

8.085

3

Mucin-16

Cell communication and signaling

Integral membrane protein

Molecular function unknown

Q8NH42

OR4KD_HUMAN

OR4K13

33

34,751

0.26

Down

4.954

3

Olfactory receptor 4K13

Cell communication and signaling

G-protein coupled receptor

G-protein coupled receptor activity

P51817

PRKX_HUMAN

PRKX

45

41,041

9.97

Up

1.351

4

cAMP-dependent protein kinase catalytic subunit PRKX

Cell communication and signaling

Serine/threonine kinase

Protein serine/threonine kinase activity

Q6ZNA4

RN111_HUMAN

RNF111

59

110,119

18.82

Up

1.665

4

E3 ubiquitin-protein ligase Arkadia

Cell communication and signaling

Unclassified

Molecular function unknown

Q16181

SEPT7_HUMAN

SEPT07_

29

50,933

4.12

Up

5.889

2

Septin-7

Cell communication and signaling

Cell cycle control protein

Protein binding

Q15036

SNX17_HUMAN

SNX17

44

53,153

10.79

Up

1.184

3

Sorting nexin-17

Cell communication and signaling

Adapter molecule

Receptor signaling complex scaffold activity

Q8IWB6

TEX14_HUMAN

TEX14

27

169,107

5.62

Up

1.288

2

Inactive serine/threonine-protein kinase TEX14

Cell communication and signaling

Dual specificity kinase

Protein threonine/tyrosine kinase activity

O43294

TGFI1_HUMAN

TGFB1I1

39

51,321

0.01

Down

4.21

2

Transforming growth factor beta-1-induced transcript 1 protein

Cell communication and signaling

Transcription regulatory protein

Transcription regulator activity

P30291

WEE1_HUMAN

WEE1

51

72,237

0.12

Down

3.019

4

Wee1-like protein kinase

Cell communication and signaling

Dual specificity kinase

Protein threonine/tyrosine kinase activity

Q9UPZ6

THS7A_HUMAN

THSD7A

30

192,854

0.01

Down

1.223

2

Thrombospondin type-1 domain-containing protein 7A

Cell communication and signaling

Unclassified

Molecular function unknown

Q9UHC1

MLH3_HUMAN

MLH3

28

166,060

0.01

Down

1.087

2

DNA mismatch repair protein Mlh3

Reg. nucleic acid metab

DNA repair protein

Protein binding

Q9UGN5

PARP2_HUMAN

PARP2

28

66,734

6.29

Up

1.04

2

Poly [ADP-ribose] polymerase 2

Reg. nucleic acid metab

DNA binding protein

Catalytic activity

Q7L014

DDX46_HUMAN

DDX46

117

117,803

8.70

Up

4.669

11

Probable ATP-dependent RNA helicase DDX46

Reg. nucleic acid metab

RNA helicase

Helicase activity

P26358

DNMT1_HUMAN

DNMT1

30

185,388

0.07

Down

1.08

2

DNA (cytosine-5)-methyltransferase 1

Reg. nucleic acid metab

DNA methyltransferase

DNA methyltransferase activity

Q8IZQ8

MYCD_HUMAN

MYOCD

34

102,561

9.73

Up

2.619

2

Myocardin

Reg. nucleic acid metab

Transcription factor

Transcription factor activity

Q15366

PCBP2_HUMAN

PCBP2

17

38,955

0.01

Down

1.318

2

Poly(rC)-binding protein 2

Reg. nucleic acid metab

RNA binding protein

RNA binding

Q5T200

ZC3HD_HUMAN

ZC3H13

33

197,203

0.02

Down

2.653

3

Zinc finger CCCH domain-containing protein 13

Reg. nucleic acid metab

Transcription regulatory protein

Transcription regulator activity

Q86UP3

ZFHX4_HUMAN

ZFHX4

35

398,157

7.38

Up

7.307

2

Zinc finger homeobox protein 4

Reg. nucleic acid metab

Transcription factor

Transcription factor activity

Q9UL58

ZN215_HUMAN

ZNF215

40

60,922

0.02

Down

9.007

2

Zinc finger protein 215

Reg. nucleic acid metab

DNA binding protein

DNA binding

Q86UQ4

ABCAD_HUMAN

ABCA13

70

580,604

0.05

Down

1.619

2

ATP-binding cassette sub-family A member 13

Transport

Transport/cargo protein

Transporter activity

P02768

ALBU_HUMAN

ALB

123

71,317

0.61

Down

4.848

6

Serum albumin

Transport

Transport/cargo protein

Transporter activity

P06727

APOA4_HUMAN

APOA4

1,502

45,371

0.56

Down

1.078

7

Apolipoprotein A-IV

Transport

Transport/cargo protein

Transporter activity

P04114

APOB_HUMAN

APOB

1,709

516,666

1.46

Up

1.306

17

Apolipoprotein B-100

Transport

Transport/cargo protein

Transporter activity

Q13439

GOGA4_HUMAN

GOLGA4

176

261,892

44.57

Up

1.39

15

Golgin sub-family A member 4

Transport

Transport/cargo protein

Transporter activity

Q9UDX3

S14L4_HUMAN

SEC14L4

67

47,070

13.48

Up

1.447

3

SEC14-like protein 4

Transport

Transport/cargo protein

Transporter activity

O14994

SYN3_HUMAN

SYN3

34

63,491

0.03

Down

1.434

2

Synapsin-3

Transport

Transport/cargo protein

Transporter activity

P21796

VDAC1_HUMAN

VDAC1

26

30,868

8.81

Up

6.002

2

Voltage-dependent anion-selective channel protein 1

Transport

Voltage-gated channel

Voltage-gated ion channel activity

Q96AW1

ECOP_HUMAN

VOPP1

32

19,839

2.46

Up

1.841

2

Vesicular, overexpressed in cancer, prosurvival protein 1

Cell growth and maintenance

Transcription regulatory protein

Transcription regulator activity

Q16610

ECM1_HUMAN

ECM1

435

62,232

0.31

Down

5.743

2

Extracellular matrix protein 1

Cell growth and maintenance

Extracellular matrix protein

Extracellular matrix structural constituent

Q9P2E2

KIF17_HUMAN

KIF17

31

115,784

0.01

Down

1.028

2

Kinesin-like protein KIF17

Cell growth and maintenance

Motor protein

Motor activity

Q9Y496

KIF3A_HUMAN

KIF3A

27

80,687

0.01

Down

1.08

2

Kinesin-like protein KIF3A

Cell growth and maintenance

Motor protein

Motor activity

Q14764

MVP_HUMAN

MVP

36

99,551

7.09

Up

3.151

4

Major vault protein

Cell growth and maintenance

Transport/cargo protein

Nucleocytoplasmic transporter activity

Q00872

MYPC1_HUMAN

MYBPC1

35

129,240

0.01

Down

1.213

2

Myosin-binding protein C, slow-type

Cell growth and maintenance

Structural protein

Structural molecule activity

P23258

TBG1_HUMAN

TUBG1

27

51,480

0.02

Down

1.934

2

Tubulin gamma-1 chain

Cell growth and maintenance

Cytoskeletal protein

Structural constituent of cytoskeleton

P02743

SAMP_HUMAN

APCS

2577

25,485

1.45

Up

9.908

9

Serum amyloid P-component

Protein metabolism

Secreted polypeptide

Binding

O76031

CLPX_HUMAN

CLPX

41

69,922

25.86

Up

2.463

3

ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial

Protein metabolism

Protease

Peptidase activity

P00740

FA9_HUMAN

F9

154

53,114

3.06

Up

3.201

2

Coagulation factor IX

Protein metabolism

Coagulation factor

Extracellular matrix binding

P07225

PROS_HUMAN

PROS1

56

77,127

2.30

Up

1.065

2

Vitamin K-dependent protein S

Protein metabolism

Coagulation factor

Protease inhibitor activity

A1L167

YE019_HUMAN

UBE2QL1

71

18,440

6.16

Up

2.05

2

Ubiquitin-conjugating enzyme E2Q-like protein 1

Protein metabolism

Unclassified

Molecular function unknown

P06681

CO2_HUMAN

C2

995

84,583

1.57

Up

1.269

7

Complement C2

Immune response

Complement protein

Complement activity

O14607

UTY_HUMAN

UTY

36

151,563

6.28

Up

3.639

4

Histone demethylase UTY

Immune response

Unclassified

Molecular function unknown

Q8WZ42

TITIN_HUMAN

TTN

44

3,843,119

4.82

Up

1.558

3

Titin

Energy Metabolism

Structural protein

Structural molecule activity

Q2LD37

K1109_HUMAN

KIAA1109

25

559,165

0.01

Down

1.46

2

Uncharacterized protein KIAA1109

Energy Metabolism

Unclassified

Molecular function unknown

Q5JU67

CI117_HUMAN

C9orf117

47

60,667

29.92

Up

5.906

2

Uncharacterized protein C9orf117

Unknown

Unclassified

Molecular function unknown

Q8IV32

CCD71_HUMAN

CCDC71

26

49,759

0.02

Down

1.543

2

Coiled-coil domain-containing protein 71

Unknown

Unclassified

Molecular function unknown

Q008S8

LFDH_HUMAN

ECT2L

39

105,782

0.33

Down

2.308

3

Epithelial cell-transforming sequence 2 oncogene-like

Unknown

Unclassified

Molecular function unknown

Q6P4F2

ADXL_HUMAN

FDX1L

22

19,737

5.58

Up

1.218

2

Adrenodoxin-like protein, mitochondrial

Unknown

Unclassified

Molecular function unknown

A6NMB9

FIGL2_HUMAN

FIGNL2

25

67,189

0.02

Down

1.825

2

Putative fidgetin-like protein 2

Unknown

Unclassified

Molecular function unknown

Q8WTR4

GDPD5_HUMAN

GDPD5

24

69,112

15.84

Up

2.584

2

Glycerophosphodiester phosphodiesterase domain-containing protein 5

Unknown

Unclassified

Molecular function unknown

Q969T7

5NT3L_HUMAN

NT5C3B

40

33,893

26.80

Up

2.534

3

7-methylguanosine phosphate-specific 5'-nucleotidase

Unknown

Unclassified

Molecular function unknown

Q68D10

SPT2_HUMAN

SPTY2D1

25

75,614

0.09

Down

3.268

2

Protein SPT2 homolog

Unknown

Unclassified

Molecular function unknown

Q7Z6W1

TMCO2_HUMAN

TMCO2

22

20,287

6.46

Up

1.541

2

Transmembrane and coiled-coil domain-containing protein 2

Unknown

Integral membrane protein

Molecular function unknown

Q9BZH6

BRWD2_HUMAN

WDR11

118

138,423

1.72

Up

3.745

7

WD repeat-containing protein 11

Unknown

Unclassified

Molecular function unknown

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