Figure 2

Main effects of group and time. (a) Significant cortical thinning in ePNS (main effect of group) compared with the whole non-PNS group was observed in left inferior temporal region (136 df). (b) ePNS group shows significant cortical thinning from baseline to FUP2 in right middle temporal gyrus (52 df). (c) Increases in cortical thickness from Baseline to FUP1 are seen in the non-PNS group within the left dorsal precentral and post-central gyri (137 df), with this increase largely driven by the sPNS subgroup. Blue color bar represents significant RFT-thresholded clusters (no significant results at the vertex level). All statistics are projected on an average surface template generated from the analyzed sample. Plot of mean thickness of peak cluster depicted per group across three scanning time points. ePNS, early persistent negative symptoms; FUP, follow-up; RFT, random field theory; sPNS, persistent negative symptoms due to secondary factors.