Figure 4

Age2×group interaction: quadratic effects of age. Significant prefrontal ROIs extracted from examination of significant age2×group interaction effect, in relation to ePNS group. ROIs (a and b) compare ePNS and entire non-ePNS group, whereas (c) compares ePNS and sPNS subgroups. Each of the three ROIs represent regions of cortical thickness with significantly different and positive quadratic relationships with age in the ePNS group only, with P-corrected<0.05. Blue color bar represents significant RFT-thresholded clusters with P-corrected=0.05 (no significant results at the vertex level). All statistics are projected on an average surface template generated from the analyzed sample. ePNS, early persistent negative symptoms; RFT, random field theory; sPNS, persistent negative symptoms due to secondary factors; ROI, region-of-interest.