Abstract
Translational research is urgently needed to turn basic scientific discoveries into widespread health gains and nowhere are these needs greater than in conditions such as schizophrenia and other psychotic disorders. In this article, we discuss one type of translational research—called T1—which is needed to take advantage of developments in the basic neurosciences and translate them into more efficacious diagnostic, preventive, and therapeutic interventions. However, ensuring that interventions from T1 research actually benefit patients will require a second form of translational research—called T2—to turn innovations into everyday clinical practice and health decision-making. Recent examples of T1 and T2 research in schizophrenia and other psychotic disorders as well as strategies for better linking T1 and T2 research agendas are covered.
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Dr Wagner reports holding stock in Johnson and Johnson. Otherwise, the authors declare that, except for income received from their primary employer, no financial support or compensation has been received from any individual or corporate entity over the past 3 years for research or professional service and there are no personal financial holdings that could be perceived as constituting a potential conflict of interest. The views and opinions expressed are those of the authors and should not be construed to represent the views of any sponsoring organization, agencies, or the US Government.
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Wang, P., Heinssen, R., Oliveri, M. et al. Bridging Bench and Practice: Translational Research for Schizophrenia and Other Psychotic Disorders. Neuropsychopharmacol 34, 204–212 (2009). https://doi.org/10.1038/npp.2008.170
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DOI: https://doi.org/10.1038/npp.2008.170
