Abstract
Alterations in white matter integrity of several cortical and subcortical circuits have been reported in relation to unipolar major depressive disorder. It is not clear whether these white matter changes precede the onset of illness. In all, 13 adolescent volunteers with no personal or family history of a psychiatric disorder (controls) and 18 adolescent volunteers with no personal history of a psychiatric illness including depression, but who were at high risk for developing unipolar depression by virtue of parental depression (high-risk youth), underwent diffusion tensor imaging studies. An automated tract-based spatial statistics method, a whole-brain voxel-by-voxel analysis, was used to analyze the scans. Population average diffusion parameter values were also calculated for each tract. Adolescents at high risk for unipolar depression had lower fractional anisotropy (FA) values in the left cingulum, splenium of the corpus callosum, superior longitudinal fasciculi, uncinate, and inferior fronto-occipital fasciculi than did controls. Altered white matter integrity in healthy adolescents at familial risk for unipolar depression suggests that it might serve as a vulnerability marker for the illness.
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Acknowledgements
This work was supported in part by grants DA14037, DA15131, DA17804, DA17805, MH62464, and MH68391 from the National Institutes of Health, and by the Sarah M. and Charles E. Seay Endowed Chair in Child Psychiatry at the UT Southwestern Medical Center. The authors do not have any financial conflicts of interest.
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Huang, H., Fan, X., Williamson, D. et al. White Matter Changes in Healthy Adolescents at Familial Risk for Unipolar Depression: A Diffusion Tensor Imaging Study. Neuropsychopharmacol 36, 684–691 (2011). https://doi.org/10.1038/npp.2010.199
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DOI: https://doi.org/10.1038/npp.2010.199
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