Table 2 Response Rates of Rats During the Drug Discrimination Study at Different Nicotine Doses (0–0.4 mg/kg) After Prazosin (0–1 mg/kg) Pretreatment

From: Erratum: Noradrenergic α1 Receptors as a Novel Target for the Treatment of Nicotine Addiction

 

Nicotine dose (mg/kg)

 

0

0.01

0.03

0.1

0.3

0.4

Vehicle

2.1±0.3

1.9±0.2

2±0.3

2±0.2

2.2±0.2

2±0.3

Prazosin 0.25 mg/kg

1.8±0.2

1.7±0.3

1.7±0.2

1.9±0.2

2.3±0.2

1.5±0.3

Prazosin 0.5 mg/kg

2±0.2

1.3±0.2

1.7±0.2

1.6±0.2

1.8±0.3

1.7±0.3

Prazosin 1 mg/kg

1.7±0.2

1.7±0.1

2±0.3

1.8±0.2

2±0.2

1.6±0.2

ANOVA F33,3=

1.7, NS

1.75, NS

1.95, NS

1.3, NS

1.4, NS

1.3, NS

  1. Data are expressed as rate of responding on levers (in lever presses/sec±SEM).
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