Figure 4 | Neuropsychopharmacology

Figure 4

From: Synaptic and Morphological Neuroadaptations in the Putamen Associated with Long-Term, Relapsing Alcohol Drinking in Primates

Figure 4

Repeated abstinence effects on drinking characteristics. (a and b) Effects of repeated abstinence on mean (± SEM) bout volumes (panel a) and bout durations (panel b). The horizontal lines indicate baseline measures of bout volume (panel a) or bout duration (panel b) averaged over 8 months preceding phase 1. (c) Cumulative records of drinking in phases 1 and 3 of monkey 25 087 chosen for matched total intake at the time of BECs (dashed line). (d) Key variables summarizing the drinking patterns in panel c for monkey 25 087 during phases 1 and 3. (e and f) Average water bout volumes (panel e) and water bout duration (panel f) were significantly greater during phase 1 than during phases 2 and 3. The horizontal lines indicate baseline measures of water bout volume (panel e) and water bout duration (panel f) averaged over 8 months preceding phase 1.

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