Figure 1
Behavioral characterization of reeler heterozygous (rl/+) mice (a–e) Characterization of anxiety- and depression-like behaviors in rl/+ mice. There were no significant differences between rl/+ and WT mice in the distance travelled (a) and in the time spent in the center (b) in the open-field test (OF). Nor there were differences in the latency to feed in the novelty-suppressed feeding test (c: NSF), in the time spent on the white compartment of the black and white box (d: BW) or in the time spent floating in the forced-swim-Test (e: FST). (f) After 3 weeks of corticosterone administration, there were no significant differences in the time spent floating in the FST between rl/+ and WT mice. (g, h) Cocaine sensitization in rl/+ mice. (g) Locomotion values for rl/+ and WT mice treated with saline. (h) Sensitization to continuous cocaine administration in rl/+ and WT mice. (i) Reelin heterozygous WT littermate controls showed significantly reduced PPI after treatment with 0.3 mg/kg MK-801 at PP levels of 78–86 dB. (j) There was a significant effect of the dose on the disruption of PPI in rl/+ mice. PPI was significantly disrupted with the 0.3 mg/kg dose (#). In figure (j), there was a significant effect of the dose, as shown by ANOVA. A posterior LSD test showed that the 0.3 mg/kg dose was significantly different from the other treatments. Significant differences were established at *p<0.05. Data are presented as mean±SEM.
