Figure 2
General characterization of Reelin-OE mice. (a, b) Reelin expression in Reelin-OE mice (b) was higher than in WT mice (a) throughout the postnatal forebrain, including the hippocampus (CA1, CA3, DG) and the cortex (NC). Arrowheads—Reelin overexpressing neurons. Scale bar: 500 μm. Scale bar of insets: 100 μm. (c) Reelin-OE mice showed increased activity during the dark phase of the light cycle. (d–h) Characterization of anxiety- and depression-like behaviors in Reelin-OE mice. There were no significant differences between WT and Reelin-OE mice in most tests (d–e: OF; f: NSF; h: FST). Reelin-OE mice spent significantly more time in the white compartment in the Black–White box test (g: BW). Significant differences were established at *p<0.05. Data are presented as mean±SEM.
