Table 1 Nicotine Intake after NAc Shell or Anterior Cingulate Infusion of α7 nAChR Antagonist or Agonist

From: Alpha7 Nicotinic Acetylcholine Receptors Modulate Motivation to Self-Administer Nicotine: Implications for Smoking and Schizophrenia

α -Conotoxin ArIB [V11L, V16D]

PNU 282987

pmol/hemisphere:

 

0

10

20

0

10

40

NAc shell

Nicotine infusions

7.4±0.92

9.4±0.75a

10.20±0.37a

7.0±0.41

2.75±0.63a

4.0±1.22a

 

Intake mg/kg

0.21±0.03

0.31±0.02a

0.34±0.01a

0.23±0.01

0.09±0.02a

0.13±0.04a

Anterior cingulate cortex

Nicotine infusions

5.2±1.02

8.4±1.17a

8.2±1.16a

5.8±0.74

5.4±0.97

5.75±1.49

 

Intake mg/kg

0.16±0.03

0.25±0.03a

0.25±0.03a

0.19±0.03

0.16±0.03

0.23±0.03

  1. Number of i.v. nicotine infusions and total nicotine intake achieved during a progressive ratio schedule of reinforcement after local infusion of either α-conotoxin ArIB [V11L, V16D] (0, 10, or 40 pmol/hemisphere) or PNU 282987 (0, 10, or 40 nmol/hemisphere) into the nucleus accumbens (NAc) shell or into the anterior cingulate cortex of rats. Antagonism of α7 nicotinic acetylcholine receptors (nAChRs) with α-conotoxin ArIB[V11L, V16D] resulted in a significant increase in nicotine intake when administered into the NAc shell or the anterior cingulate cortex. In contrast, local infusion of an agonist of nAChRs,
  2. PNU 282987, led to significant decreases in nicotine intake, but only when administered into the NAc shell.
  3. aIndicates significantly different from vehicle infusion (p<0.05; n=4–5 per group).
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