Table 2 Genotypic and Allelic Distributions for SNPs in the RELA Gene Between Patients in Schizophrenia and Controls
From: Variants of the RELA Gene are Associated with Schizophrenia and their Startle Responses
(a) In males | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Marker | M/m | Location | SCZ ( N =623) | CON ( N =773) | Genotypic p value (df=2) | SCZ | CON | Allelic p value (df=1) | OR (95%CI) | |||||
SNP ID | Position a | M/M | M/m | m/m | M/M | M/m | m/m | MAF | ||||||
SNP1 | 10728386 | C/T | Intron 10 | 0.35 | 0.47 | 0.18 | 0.28 | 0.48 | 0.23 | 0.014 | 0.42 | 0.48 | 0.0030 | 0.79 (0.68–0.92) |
SNP2 | 10730962 | G/C | Intron 8 | 0.76 | 0.23 | 0.01 | 0.75 | 0.24 | 0.01 | 0.88 | 0.12 | 0.13 | 0.69 | 0.95 (0.76–1.20) |
SNP3 | 10733141 | G/A | Intron 5 | 0.34 | 0.47 | 0.19 | 0.28 | 0.48 | 0.24 | 0.0080 | 0.42 | 0.48 | 0.0016 | 0.78 (0.67–0.91) |
SNP4 | 10735731 | C/T | Intron 1 | 0.30 | 0.48 | 0.22 | 0.38 | 0.45 | 0.16 | 0.0022 | 0.46 | 0.39 | 0.00037 | 1.32 (1.13–1.54) |
(b) In females | ||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Marker | M/m | Location | SCZ ( N =601) | CON ( N =890) | Genotypic p value (df=2) | SCZ | CON | Allelic p value (df=1) | OR (95%CI) | |||||
SNP ID | Position a | M/M | M/m | m/m | M/M | M/m | m/m | MAF | ||||||
SNP1 | 10728386 | C/T | Intron 10 | 0.30 | 0.50 | 0.20 | 0.30 | 0.48 | 0.23 | 0.52 | 0.45 | 0.47 | 0.45 | 0.94 (0.81–1.10) |
SNP2 | 10730962 | G/C | Intron 8 | 0.80 | 0.19 | 0.01 | 0.77 | 0.22 | 0.01 | 0.35 | 0.11 | 0.12 | 0.16 | 0.84 (0.67–1.07) |
SNP3 | 10733141 | G/A | Intron 5 | 0.30 | 0.49 | 0.21 | 0.29 | 0.47 | 0.24 | 0.52 | 0.45 | 0.47 | 0.32 | 0.93 (0.80–1.08) |
SNP4 | 10735731 | C/T | Intron 1 | 0.31 | 0.49 | 0.20 | 0.34 | 0.49 | 0.16 | 0.13 | 0.45 | 0.41 | 0.054 | 1.16 (1.00–1.35) |
