Table 1 Expression Levels of Genes Belonging to GR Functionality (FKBP-4, FKBP-5, and GR), Inflammation (IL-1α, IL-1β, IL-4, IL-6, IL-7, IL-8, IL-10, TNF-α, and MIF), and Neuroplasticity (BDNF, p11, and VGF) in Controls and Depressed Patients with Statistics (p and F values and Percentage Changes)
Gene | Controls (mean±SEM) | Patients (mean±SEM) | F value | p -Value | Percentage change (%) |
|---|---|---|---|---|---|
FKBP-4 | 0.99±0.01 | 0.98±0.01 | 0.2 | 0.70 | −1 |
FKBP-5 | 0.99±0.02 | 1.26±0.02 | 69.4 | <0.0001 | +27 |
GR | 1.03±0.02 | 0.85±0.01 | 63.2 | <0.0001 | −18 |
IL-1α | 0.96±0.04 | 1.00±0.02 | 0.9 | 0.3 | +4 |
IL-1β | 1.03±0.03 | 1.51±0.03 | 117.9 | <0.0001 | +48 |
IL-4 | 0.99±0.02 | 0.90±0.02 | 5.6 | 0.02 | −9 |
IL-6 | 1.08±0.02 | 1.32±0.01 | 86.3 | <0.0001 | +24 |
IL-7 | 1.03±0.05 | 0.99±0.02 | 0.9 | 0.36 | −4 |
IL-8 | 1.00±0.04 | 1.01±0.01 | 0.2 | 0.68 | +1 |
IL-10 | 1.00±0.02 | 1.02±0.01 | 1.1 | 0.31 | +2 |
TNF-α | 0.97±0.04 | 1.55±0.04 | 87.7 | <0.0001 | +58 |
MIF | 0.98±0.04 | 1.30±0.03 | 34.8 | <0.0001 | +32 |
BDNF | 0.95±0.04 | 0.71±0.01 | 46.5 | <0.0001 | −24 |
p11 | 1.01±0.02 | 0.85±0.03 | 12.1 | 0.001 | −16 |
VGF | 1.01±0.04 | 0.65±0.04 | 37.3 | <0.0001 | −36 |
