Table 3 Adjusted R2 Values and Significance of Linear Regression Model to Assess the Contribution of TNF-α, MIF, and IL-1β, Alone or in Combination, in Predicting the Treatment Response in the Whole Sample, in the Escitalopram-Treated Group and in the Nortriptyline-Treated Group
Whole sample ( n =74) | Escitalopram-treated group ( n =38) | Nortriptyline-treated group ( n =36) | |
|---|---|---|---|
Effects of each single cytokine as predictor of treatment response | |||
TNF-α | Adjusted R2=0.19, p<0.0001 | Adjusted R2=0.13, p=0.016 | Adjusted R2=0.45, p<0.0001 |
MIF | Adjusted R2=0.37, p<0.0001 | Adjusted R2=0.51, p<0.0001 | Adjusted R2=0.29, p<0.0001 |
IL-1β | Adjusted R2=0.31, p<0.0001 | Adjusted R2=0.27, p=0.001 | Adjusted R2=0.41, p<0.0001 |
Combined effects of cytokines as predictor of treatment response | |||
TNF-α | Adjusted R2=0.19, p<0.0001 | Adjusted R2=0.13, p=0.016 | Adjusted R2=0.45, p<0.0001 |
TNF-α+MIF | Adjusted R2=0.40, p<0.0001 | Adjusted R2=0.50, p<0.0001 | Adjusted R2=0.47, p<0.0001 |
TNF-α+MIF+IL-1β | Adjusted R2=0.46, p<0.0001 | Adjusted R2=0.53, p<0.0001 | Adjusted R2=0.48, p<0.0001 |
