Table 3 Summary of the Effects of Intra-NAcbS and Intra-NAcbC Infusions of ATO and MPH on 5-CSRTT Performance

From: Norepinephrine and Dopamine Modulate Impulsivity on the Five-Choice Serial Reaction Time Task Through Opponent Actions in the Shell and Core Sub-Regions of the Nucleus Accumbens

 

ATO

MPH

 

0.0

0.5

1.5

5.0

0.0

0.5

1.5

5.0

NAcbS

 Accuracy (%)

87.3±0.9

89.2±1.1

87.6±2.9

89.6±1.1

87.5±2.5

90.7±1.0

88.3±2.0

84.4±1.5

 Omissions (%)

5.2±1.1

4.6±2.0

5.0±2.3

8.2±2.9

8.2±3.4

5.4±2.0

6.0±2.3

11.0±1.9

 Perseverative NPs

35.4±4.2

46.4±8.5

45.8±11.1

47.8±13.3

43.6±11.8

52.0±16.5

53.4±16.5

81.0±14.5

 Correct latency (ms)

513.1±29.0

519.7±32.3

497.5±32.9

550.1±46.2

480.3±19.2

444.3±19.5

432.7±17.4*

462.7±13.2

 Incorrect latency (ms)

1297.5±174.3

1118.2±209.3

1350.1±329.7

1665.3±262.1

1221.0±179.4

995.6±197.3

1046.3±120.1

1192.2±187.9

 Collect latency (ms)

1728.2±229.0

2134.2±494.9

2022.9±487.0

1968.9±342.5

1642.7±226.3

1576.6±118.1

2028.3±330.9

1675.2±135.4

NAcbC

 Accuracy (%)

79.1±1.6

—

80.2±2.2

76.7±3.9

79.2±3.8

78.2±3.7

69.9±8.2

74.7±5.2

 Omissions (%)

9.8±2.1

—

9.2±1.7

11.3±1.7

7.6±1.4

13.3±5.9

20.7±7.1

20.3±3.3

 Perseverative NPs

76.9±10.8

—

63.7±6.1

85.7±17.7

55.3±6.9

61.3±8.9

58.4±7.7

67.6±9.0

 Correct latency (ms)

576.5±35.2

—

633.1±60.4

672.3±78.3

575.9±37.5

647.6±43.8

609.1±43.7

608.0±60.4

 Incorrect latency (ms)

1174.3±94.3

—

1337.0±130.2

1503.2±177.4

1430.1±175.9

1458.0±137.5

1558.0±148.5

1937.4±208.2

 Collect latency (ms)

1552.7±88.2

—

1545.2±108.3

1612.8±104.6

1701.0±69.7

1770.5±97.4

1639.5±54.3

1591.7±63.7

  1. *p<0.05, compared with vehicle-treated animals.
  2. Data are shown as mean (± SEM).
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