Figure 4
(a) Relative differences (broken line: less, non-broken line greater) between controls and multiply detoxified (MDTx) patients in functional neuronal connections between insula and amygdala as seed regions, and other brain areas. The sign and magnitude of the difference (patient beta coefficient minus control beta coefficient) is given for each neuronal connection. (b) Relationships (r values) between intensity of connectivity and measures of dependency (number of detoxifications (#DTx), Severity of Alcohol Dependency Questionnaire (SADQ) score, and DCQ score). For lateralization of brain areas see Supplementary Table S5, S6, S7 and S8 in the Supplementary Material). DLPFC, dorsolateral prefrontal cortex; OFC, orbitofrontal cortex; VLPFC, ventrolateral PFC.
