Table 2 Modulation of Swim Stress-Induced c-Fos Expression by NAcb-DBS in HAB mice

From: Behavioral and Neurobiological Effects of Deep Brain Stimulation in a Mouse Model of High Anxiety- and Depression-Like Behavior

Brain regions (brain level)

HAB-Sham

HAB-DBS

P -value

Cortical areas

 Prelimbic cortex (+1.94 mm and +1.70 mm)

15.8±0.5

13.3±0.5

0.008

 Infralimbic cortex (+1.94 mm and +1.70 mm)

11.7±0.4

13.0±0.6

0.163

 Cingulate cortex 1 (+1.94 mm and +1.70 mm)

31.6±2.4

34.2±2.7

0.706

 Orbitofrontal cortex, lateral (+1.94 mm)

33.4±3.7

43.3±2.0

0.027

Thalamus

 Lateral habenular nucleus (−1.06 mm)

50.9±1.8

57.8±0.9

0.003

 Medial habenular nucleus (−1.06 mm)

28.9±1.1

28.0±2.6

0.770

Hippocampus

 Dentate gyrus (−0.94 to −3.80 mm)

3040±137.2

3664±234.7

0.040

 Dentate gyrus, superior arm

(−0.94 to −3.80 mm)

2356±98.6

2924.3±94.0

<0.001

 Dentate gyrus, inferior arm

(−0.94 to −3.80 mm)

738.7±57.7

911.0±66.4

0.068

  1. Data represent means±SEM numbers of c-Fos-positive cells per 0.01 mm2 (except dentate gyrus of the hippocampus where total c-Fos expression was quantified). N=9–11 animals per group.Bold and italic numerals indicate significant differences in the number of c-Fos-positive cells between Nacb-DBS and NAcb-sham HAB mice. P<0.05.
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