Figure 5
GABA transmission in dorsolateral striatum (DLS) and dorsomedial striatum (DMS) is depressed after binge-like ethanol consumption. (a, b) Representative traces of miniature inhibitory post-synaptic currents (mIPSCs) recorded from medium spiny neurons (MSNs) located in the DLS (a) and DMS (b) of water and ethanol drinking mice 4–8 days after the last drinking session. (c) Frequency of mIPSCs recorded in medium spiny neurons in the DLS and DMS of water control mice (white) and ethanol mice (black). (d) Amplitude of mIPSCs recorded from neurons in the DLS and DMS of water control mice (white) and ethanol mice (black). (e, f) Mean mIPSCs frequency in neurons of the DLS (e) and DMS (f) as a function of the mean BEC achieved during the DID session for ethanol drinking mice. Dotted line and shade mark the mean and SEM, respectively, for the mIPSCs frequency of neurons in water control mice. All data are expressed as mean ±SEM. *Denotes P<0.05.
