Figure 4 | Neuropsychopharmacology

Figure 4

From: Deficiency of Schnurri-2, an MHC Enhancer Binding Protein, Induces Mild Chronic Inflammation in the Brain and Confers Molecular, Neuronal, and Behavioral Phenotypes Related to Schizophrenia

Figure 4

Reduced Arc induction in Shn-2 KO mice was observed after foot shocks in a novel environment. (a–c) Shn-2 KO mice were mated with transgenic mice expressing dVenus under the Arc promoter. Representative images of both genotypes are shown. (d) In Shn-2 KO mice, Arc-dVenus expression was greatly reduced in the DG and other regions of cortex and amygdala. Arc, activity-regulated cytoskeleton-associated protein. Scale bars indicate 1 mm (a), 250 μm (b), and 100 μm (c). MO, medial orbital cortex; FA, frontal association cortex; PL, prelimbic cortex; M1, primary motor cortex; CG, cingulate cortex; S1, somatosensory cortex; CA, central amygdaloid nucleus; LA, lateral amygdaloid nucleus.

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