Figure 1
Conditioned place preference for 2 mg/kg (a) and 5 mg/kg (b) D-amphetamine and 20 mg/kg cocaine (c); (stimulants were administered in the less-preferred chamber): data are expressed as the time spent in the drug-associated compartment before (pretest) and after (test) D-amphetamine or cocaine treatment. D-amphetamine (2 mg/kg and 5 mg/kg) and cocaine induced significant place preference in both, wild type (WT) and knockout (KO) mice (paired two-tailed Student’s t-test, p<0.01). Repeated measures two-way analysis of variance (ANOVA) revealed no significant treatment × genotype effects (p<0.05). (a) WT n=7, KO n=13, (b) WT n=10, KO n=10, (c) WT n=7, KO n=5.
