Figure 4
(a) D-amphetamine-induced dopamine release in the dorsal striatum of wild type (WT) and knockout (KO) animals in vivo: Microdialysis probes were inserted into the right dorsal striatum of WT and KO mice. Mice were allowed to recover for 24 h from the surgery before measurement of baseline dopamine concentrations. The day after, mice were injected with D-amphetamine (5 mg/kg i.p.) and dopamine dialysates were collected for 2 h. Amphetamine-induced dopamine release was normalized to baseline dopamine levels (see Figure 2 legend) and is presented as percentage of basal level. (b) Densitometric analysis of βCaMKII protein levels in the striatum of WT and KO mice: bands were normalized to tubulin; n=7; Student’s t-test, *p<0.05. (c) Densitometric analysis of PKC protein levels in the striatum of WT and KO mice: bands were normalized to tubulin; n=9; Student’s t-test, p>0.05
