Figure 1
Effect of L-Dopa and L-Dopa+Ddci (dopa-decarboxylase inhibitor) treatments on the Mecp2 null phenotype. The number of animals used in each experiment was 30 for wild-type (WT) control, 37 for vehicle, 40 for L-Dopa+Ddci, 30 for L-Dopa, and 15 for Ddci. (a) Measurement of mice body weight during treatment. No effect on body weight was observed after the treatments in the Mecp2 KO mice. (b) Plots showing ‘Score Test’ (Guy et al, 2001) improvement upon L-Dopa+Ddci treatment related to mobility, tremor, and breathing. (c) Plots showing ‘Score Test’ (Guy et al, 2001) improvement related to gait, hindlimb clasping, and general conditions that are less affected by the treatments. (d) Plot of total average symptom scores showing ‘Score Test’ (Guy et al, 2001) improvement in Mecp2 KO-treated mice upon L-Dopa+Ddci treatment. For the described pairwise comparisons, a Tukey HSD post hoc test was performed after the one-way analysis of variance. *p<0.05, **p<0.01, and ***p<0.001.
