Log in or create a free account to read this content
Gain free access to this article, as well as selected content from this journal and more on nature.com
or
References
Bhutani N, Burns DM, Blau HM (2011). DNA demethylation dynamics. Cell 146: 866–872.
Feldmann A, Ivanek R, Murr R, Gaidatzis D, Burger L, Schuebeler D (2013). Transcription factor occupancy can mediate active turnover of DNA methylation at regulatory regions. PLoS Genet 9: e1003994.
Klengel T, Mehta D, Anacker C, Rex-Haffner M, Pruessner JC, Pariante CM et al (2013). Allele-specific FKBP5 DNA demethylation mediates gene-childhood trauma interactions. Nat Neurosci 16: 33–41.
Kress C, Thomassin H, Grange T (2006). Active cytosine demethylation triggered by a nuclear receptor involves DNA strand breaks. Proc Natl Acad Sci USA 103: 11112–11117.
Manuck SB, McCaffery JM (2014). Gene-environment interaction. In: Fiske ST, (ed). Annual Review of Psychology, Vol 65. Annual Reviews: Palo Alto, CA. pp 41–70.
Zannas AS, Binder EB (2014). Gene-environment interactions at the FKBP5 locus: sensitive periods, mechanisms and pleiotropism. Genes Brain Behav 13: 25–37.
Author information
Authors and Affiliations
Corresponding author
PowerPoint slides
Rights and permissions
About this article
Cite this article
Klengel, T., Binder, E. FKBP5 Allele-Specific Epigenetic Modification in Gene by Environment Interaction. Neuropsychopharmacol 40, 244–246 (2015). https://doi.org/10.1038/npp.2014.208
Published:
Issue date:
DOI: https://doi.org/10.1038/npp.2014.208
This article is cited by
-
Genetic association of FKBP5 with trait resilience in Korean male patients with alcohol use disorder
Scientific Reports (2021)
-
Three-way interaction effects of early life stress, positive parenting and FKBP5 in the development of depressive symptoms in a general population
Journal of Neural Transmission (2021)
-
Identification of dynamic glucocorticoid-induced methylation changes at the FKBP5 locus
Clinical Epigenetics (2019)
-
Umwelt und Epigenetik
Der Nervenarzt (2019)
-
Type 2 diabetes and cardiometabolic risk may be associated with increase in DNA methylation of FKBP5
Clinical Epigenetics (2018)