Figure 2
Hippocampal and substantia nigra (SN) responses to novel compared to familiar objects. (a) Right hippocampal region showing increased activation to novel compared with familiar objects (main effect of novelty) Family Wise Error (FWE) corrected p=0.025 for hippocampal region of interest. (b) Contrast estimates for the right hippocampal region following placebo (blue) and vaccine (red). (c) SN novelty × inflammation interaction, FWE corrected p=0.031 (right), p=0.051 (left). (d) Contrast estimates for the right and left SN following placebo (blue) and vaccine (red) demonstrating a significant reduction in SN responses to novel compared with familiar stimuli bilaterally following inflammation.
